September

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29.09.2021

Mapping protein interactions in the active TOM-TIM23 supercomplex

Authors Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz Ch, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Henning Urlaub H, Rehling P Journal Nature Communications Citation Nat Commun 12, 5715 (2021) Abstract Nuclear-encoded mitochondrial proteins destined for the matrix have to be
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27.09.2021

Virtual Cryo-EM symposium at MBExC

The MBExC celebrated the inauguration of its cryo-EM platform at the University of Göttingen hosted by Rubén Fernández Busnadiego. Electron microscopy is central to MBExC’s mission of bridging the scales in biological imaging. In the virtual symposium MBExC speakers and colleagues from the international cryo-EM community presented exciting MBExC research
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21.09.2021

Management of Metadata Types in Basic Cardiological Research

Authors Kusch H, Kossen R, Suhr M, Freckmann L, Weber L, Henke C, Lehmann C, Rheinländer S, Aschenbrandt G, Kühlborn LK, Marzec B, Menzel J, Schwappach B, Zelarayán LC, Cyganek L, Antonios G, Kohl T, Lehnart SE, Zoremba M, Sax U, Nussbeck SY Journal Studies in Health Technology and Informatics
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20.09.2021

Biallelic variants in YRDC cause a developmental disorder with progeroid features

Authors Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmüller J, Thiele H, Nürnberg P, Isensee J, Li Y, Müller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, Wollnik B Journal
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17.09.2021

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion

Authors Kerimoglu C, Pham L, Tonchev AB, Sakib MS, Xie Y, Sokpor G, Ulmke PA, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong RH, Huttner WB, Nguyen HP, Stoykova
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16.09.2021

Structure of an inactive RNA polymerase II dimer

Authors Aibara S, Dienemann Ch, Cramer P Journal Nucleic Acids Research Citation Nucleic Acids Research, 2021; Sep 16, gkab783 Abstract Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it
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15.09.2021

RIM-Binding Protein 2 Organizes Ca2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse

Authors Butola T, Alvanos T, Hintze A, Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T Journal Journal of Neuroscience Citation J. Neurosci. 2021, 41 (37) 7742-7767 Abstract Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the presynaptic active zone (AZ). By binding to RIM, bassoon
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15.09.2021

Structural basis of human transcription–DNA repair coupling

Authors Kokic G, Wagner FR, Chernev A, Urlaub H, Cramer P Journal Nature Citation Nature 2021 Abstract Transcription-coupled DNA repair removes bulky DNA lesions from the genome and protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits
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15.09.2021

Patrick Cramer receives Aminoff Prize

MBExC member Patrick Cramer was awarded this year’s Aminoff Prize together with Elena Conti, Germany, and Seth Darst, USA, for the investigation of cellular systems for the production, transport and quality control of RNA. The Gregori Aminoff Prize of the Royal Swedish Academy of Sciences honors every year scientific advances in
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08.09.2021

Instant three-color multiplane fluorescence microscopy

Authors Gregor I, Butkevich E, Enderlein J, Mojiri S Journal Biophysical Reports Citation Biophysical Reports 1 (1), 8 Sep 2021, 100001 Abstract One of the most widely used microscopy techniques in biology and medicine is fluorescence microscopy, offering high specificity in labeling as well as maximal sensitivity. For live-cell imaging,
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