2021

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08.12.2021

How matrix recycling keeps the brain flexible

Scientists of the Cluster of Excellence Multiscale Bioimaging describe a new mechanism that supports synaptic plasticity in the adult brain. Published in Nature Communications. The extracellular matrix (ECM) gives cell assemblies their structure and plays an important role in cell communication and control. In the adult brain, it forms lattices
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08.12.2021

How matrix recycling keeps the brain flexible

Scientists of the Cluster of Excellence Multiscale Bioimaging describe a new mechanism that supports synaptic plasticity in the adult brain. Published in Nature Communications. The extracellular matrix (ECM) gives cell assemblies their structure and plays an important role in cell communication and control. In the adult brain, it forms lattices
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03.12.2021

Technology transfer award for light microscopes with molecular resolution

For the entrepreneurial implementation of research results in the field of high-resolution light microscopy, abberior Instruments GmbH, the Max Planck Innovation GmbH and the Max Planck Institute for Biophysical Chemistry receive the technology transfer award from the German Physical Society. In 2012, abberior emerged from the NanoBiophotonics department of Nobel
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02.12.2021

Funsho Fakuade receives Dissertation Prize

The MBExC congratulates Hertha Sponer College member Funsho Fakuade, Institute of Pharmacology and Toxicology at the UMG, for receiving the Dissertation Prize 2020 of the Universitätsbund Göttingen e.V. His excellently evaluated dissertation on the assessment of altered atrial physiology in patients with atrial fibrillation was chosen by a selection committee
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30.11.2021

Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography

Authors Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T Journal PNAS Citation Proc Natl Acad Sci U S A . 2021 Nov 30;118(48):e2113835118 Abstract We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in neuropathologically healthy and Alzheimer’s disease (AD) individuals, based on phase-contrast X-ray computed
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26.11.2021

X-ray view of neurodegenerative diseases

Researchers at the University and University Medical Center Göttingen, in collaboration with the Cluster of Excellence Multiscale Bioimaging and the Collaborative Research Center Mathematics of Experimentation, have found a new way to measure and quantify neuronal tissue architecture in three dimensions and at high resolution. Using their specialized X-ray imaging,
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24.11.2021

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.
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23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”.   Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The
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23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”. Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The machinery
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22.11.2021

Gene therapy against deafness

One in 500 children is born with hearing impairment, and in 50 to 70 percent of cases a genetic defect is the cause. In a joint research project, a team led by Rüdiger Behr (German Primate Center) and MBExC spokesperson Tobias Moser (University Medical Center Göttingen) in cooperation with scientists
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