February

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10.02.2021

The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons

Authors Sertel SM, von Elling-Tammen MS, Rizzoli SO Journal Journal of Neuroscience Citation J Neurosci. 2021 Feb 10;41(6):1157-1173. Abstract The activity and the metabolism of the brain change rhythmically during the day/night cycle. Such rhythmicity is also observed in cultured neurons from the suprachiasmatic nucleus, which is a critical center
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"Heart patch" made from stem cells to repair the heart muscle in heart failure enters first clinical trial worldwide. Photo: umg

09.02.2021

“Heart patch” made from stem cells enters world’s first clinical trial

First application in humans: The BioVAT-HF-DZHK20 study intends to investigate the use of heart muscle tissue derived from stem cells for treatment of patients with severe heart failure. The incorporation of heart muscle tissue cultivated in the laboratory is intended to sustainably improve the pumping function of diseased hearts. The
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08.02.2021

Transcription activation depends on the length of the RNA polymerase II C-terminal domain

Authors Sawicka A, Villamil G, Lidschreiber M, Darzacq X, Dugast-Darzacq C, Schwalb B, Cramer P Journal EMBO Journal Citation EMBO J. 2021 Feb 8:e107015. Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail-like, intrinsically disordered carboxy-terminal domain (CTD) comprised of heptad-repeats, that functions in coordination of the transcription cycle
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08.02.2021

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling

Authors Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T Journal Development Citation Development. 2021 Feb 8;148(3):dev188276. Abstract Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels,
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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Synaptic diversity broadens the range of sound we can hear

Hearing occurs when sensory hair cells in the inner ear convert sound into neural signals transmitted to the brain. The sensory hair cells have about a dozen communication points with the auditory nerve fibers, called synapses. Scientists from the Institute for Auditory Neuroscience at the University Medical Center Göttingen discovered
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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Synaptic diversity broadens the range of sound we can hear

Hearing occurs when sensory hair cells in the inner ear convert sound into neural signals transmitted to the brain. The sensory hair cells have about a dozen communication points with the auditory nerve fibers, called synapses. Scientists from the Institute for Auditory Neuroscience at the University Medical Center Göttingen discovered
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05.02.2021

Two mechanisms drive pronuclear migration in mouse zygotes

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei
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Dr. Alexander Dieter has been awarded the "Friedrich Hirzebruch Doctoral Prize for Mathematics, Natural and Engineering Sciences" 2021 by the German National Academic Foundation. Photo: private

05.02.2021

Awarded doctorate in neuroscientific hearing research

Dr. Alexander Dieter, a young neuroscientist and first author of the MBExC publication “μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve” (published in summer 2020 in the EMBO Molecular Medicine Journal), has been awarded with the doctoral thesis award 2021 of the Studienstiftung des Deutschen Volkes.
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04.02.2021

Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy

Authors Reinert MC, Pacheu-Grau D, Catarino CB, Klopstock T, Ohlenbusch A, Schittkowski M, Wilichowski E, Rehling P, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2021 Feb 4;16(1):64. Abstract Background: Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder and characterized by acute
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04.02.2021

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

Authors Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S. Journal Nature Communications Citation Nat Commun. 2021 Feb 4;12(1):782. Abstract The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins,
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