January

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30.01.2021

Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders

Authors Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I Journal Acta Neuropathologica Citation Acta Neuropathol. 2021 Jan 30. Abstract Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as Parkinson’s disease (PD), Parkinson’s
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In the HFpEF-stress-DZHK17 study, the scientists led by Prof. Dr. Andreas Schuster (UMG) were able to show that diastolic heart failure can be precisely diagnosed with the help of a new non-invasive real-time MRI technology and thus a cardiac catheter examination can possibly be avoided in the future. Photo: umg/Matthias Seehase

29.01.2021

Alternative to cardiac catheter examination

Diastolic heart failure can be reliably detected with the help of a newly developed magnetic resonance imaging (MRI) technology, shows a study by the Göttingen partner site of the German Centre for Cardiovascular Research (DZHK). Until now, this was only possible with an invasive cardiac catheter examination, which is very
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29.01.2021

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

Authors Füllbrunn N, Li Z, Jorde L, Richter CP, Kurre R, Langemeyer L, Yu C, Meyer C, Enderlein J, Ungermann C, Piehler J, You C Journal Elife Citation Elife. 2021 Jan 29;10:e62501. Abstract Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic
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28.01.2021

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci

Authors Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras K, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N Journal Circulation Research Citation Circ Res. 2021 Jan 28. Abstract Rationale: Mitral valve prolapse (MVP) is a common valvopathy
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28.01.2021

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Authors Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R Journal Molecular Cell Citation Mol Cell. 2021 Jan 28:S1097-2765(21)00016-2. Abstract In response to stress, human cells coordinately downregulate transcription and translation of housekeeping
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27.01.2021

Multiscale quantile segmentation

Authors Vanegas LJ, Behr M, Munk A Journal Journal of the American Statistical Association Citation Journal of the American Statistical Association. 2021 Jan 27. Abstract We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does
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26.01.2021

Patrick Cramer receives the 2021 Louis-Jeantet Prize for Medicine

The research award is one of the most prestigious in Europe and endowed with 500,000 Swiss francs. With this prize the Louis-Jeantet Foundation honors the director at the Max Planck Institute (MPI) for Biophysical Chemistry and member of the MBExC for his pioneering work in the field of gene transcription.
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25.01.2021

Carola Gregor and Antoine Huet are new MBExC Junior Fellows

The Cluster of Excellence “Multiscale Bioimaging” (MBExC) welcomes Dr. Carola Gregor and Dr. Antoine Huet as new Junior Fellows starting in January 2021 for 3 years. Dr. Carola Gregor will focus with her project Bioluminescence imaging of neurons and cardiomyocytes  on the bioluminescence system from bacteria to develop new tools
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25.01.2021

Exploring early time points of vimentin assembly in flow by fluorescence fluctuation spectroscopy

Authors Perego E, Köster S Journal Lab on a Chip Citation Lab Chip. 2021 Jan 25. Abstract Despite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device and combine it
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25.01.2021

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

Authors Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE Journal Circulation Research Citation
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