2020

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30.10.2020

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity.

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore
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30.10.2020

Defining the architecture of the human TIM22 complex by chemical crosslinking

Authors Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, Deckers M, Rehling P Journal FEBS Letters Citation FEBS Lett. 2020 Oct 30. Abstract The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The Translocase of the Inner
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28.10.2020

Connexin hemichannels in atrial fibrillation – Orphaned and irrelevant?

Authors Fakuade FE, Tomsits P, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2020 Oct 28:cvaa308. Abstract No abstract available DOI 10.1093/cvr/cvaa308 Pubmed Link  
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26.10.2020

Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation

Authors Sarkar A, Wang I, Enderlein J, Derouard J, Delon A Journal Optics Express Citation Opt Express. 2020 Oct 26;28(22):32936-32954. Abstract Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to image objects hidden behind visually opaque layers. Here, we show that a correlation analysis
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The cartoon illustration shows a part of the apoferritin protein (yellow) with a tyrosine side chain highlighted in grey. The amino acid tyrosine consists of several atoms that are individually recognizable in the structure (red grid structures). © Holger Stark / MPI-BPC

21.10.2020

World record resolution in cryo electron microscopy

Holger Stark and his team at the Max Planck Institute (MPI) for Biophysical Chemistry have broken a crucial resolution barrier in cryo electron microscopy. The scientists succeeded in observing single atoms in a protein structure and taking the sharpest images ever with this method. Such unprecedented details are essential to
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Cells cultured in the laboratory (cyan). Artificial viruses that mimic SARS-CoV-2 (magenta) infect the cells via ACE2 and neuropilin-1. Source: DZNE/ Liliana Pedro-Domingues

20.10.2020

Coronavirus: Study finds further door opener into the cell

The coronavirus SARS-CoV-2 is known to infect cells via the receptor ACE2. An international research team under German-Finnish coordination has now identified neuropilin-1 as a factor that can facilitate SARS-CoV-2 entry into the cells’ interior. Neuropilin-1 is localized in the respiratory and olfactory epithelia, which could be a strategically important
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20.10.2020

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Authors Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu
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19.10.2020

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

Authors Wildemann B, Jarius S, Franz J, Ruprecht K, Reindl M, Stadelmann C Journal Acta Neuropathologica Citation Acta Neuropathol. 2020 Oct 19. Abstract no abstract available DOI 10.1007/s00401-020-02236-5 Pubmed Link  
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14.10.2020

Heterogeneous Idealization of Ion Channel Recordings — Open Channel Noise

Authors Pein F, Bartsch A, Steinem C, Munk A Journal IEEE Transactions on Nanobioscience Citation IEEE Trans Nanobioscience. 2020 Oct 14;PP. Abstract We propose a new model-free segmentation method for idealizing ion channel recordings. This method is designed to deal with heterogeneity of measurement errors. This in particular applies to
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09.10.2020

Confocal Fluorescence-Lifetime Single-Molecule Localization Microscopy

Authors Thiele JC, Helmerich DA, Oleksiievets N, Tsukanov R, Butkevich E, Sauer M, Nevskyi O, Enderlein J Journal ACS Nano Citation ACS Nano. 2020 Oct 9. Abstract Fluorescence lifetime imaging microscopy is an important technique that adds another dimension to intensity and color acquired by conventional microscopy. In particular, it
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