2020

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28.12.2020

[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates

Authors Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K Journal European Journal of Nuclear Medicine and Molecular Imaging Citation Eur J Nucl Med Mol Imaging. 2020 Dec 28.
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24.12.2020

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Authors Lohrberg M, Winkler A, Franz J, van der Meer F, Ruhwedel T, Sirmpilatze N, Dadarwal R, Handwerker R, Esser D, Wiegand K, Hagel C, Gocht A, König FB, Boretius S, Möbius W, Stadelmann C, Barrantes-Freer A Journal Acta Neuropathologica Communications Citation Acta Neuropathol Commun. 2020 Dec 24;8(1):224. Abstract Demyelinated
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23.12.2020

Integrator is a genome-wide attenuator of non-productive transcription

Authors Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH Journal Molecular Cell Citation Mol Cell. 2020 Dec 23:S1097-2765(20)30906-0. Abstract Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator
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22.12.2020

Single-Cell Optical Action Potential Measurement in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Authors Seibertz F, Reynolds M, Voigt N Journal Journal of Visualized Experiments Citation J Vis Exp. 2020 Dec 22;(166). Abstract Conventional intracellular microelectrode techniques to quantify cardiomyocyte electrophysiology are extremely complex, labor intensive, and typically carried out in low throughput. Rapid and ongoing expansion of induced pluripotent stem cell (iPSC)
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21.12.2020

A sensory cell diversifies its output by varying Ca2+ influx-release coupling among active zones

Authors Özcete Ö, Moser T Journal EMBO Journal Citation EMBO J (2020)e106010. Abstract The cochlea encodes sound pressures varying over six orders of magnitude by collective operation of functionally diverse spiral ganglion neurons (SGNs). The mechanisms enabling this functional diversity remain elusive. Here, we asked whether the sound intensity information,
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21.12.2020

Cancer and Parkinson’s Disease: Common Targets, Emerging Hopes

Authors Filippou PS, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2020 Dec 21. Abstract Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. At first sight, the two fields do not seem to share much in common and, if anything, might be placed on opposite
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21.12.2020

Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells

Authors Effertz T, Moser T, Oliver D Journal Faculty Reviews Citation Faculty Reviews  2020, 9:24. Abstract In recent years, genetics, physiology, and structural biology have advanced into the molecular details of the sensory physiology of auditory hair cells. Inner hair cells (IHCs) and outer hair cells (OHCs) mediate two key
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16.12.2020

Small-molecule inhibitors of human mitochondrial DNA transcription

Authors Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG Journal Nature
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15.12.2020

Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei

Authors Wittmeier A, Cassini C, Töpperwien M, Denz M, Hagemann J, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Rad (2021) 28. Abstract X-rays are emerging as a complementary probe to visible-light photons and electrons for imaging biological cells. By exploiting their small wavelength
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10.12.2020

Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-based Exchangeable Fluorophores

Authors Glogger M, Spahn C, Enderlein J, Heilemann M Journal Angewandte Chemie (International Edition) Citation Angew Chem Int Ed Engl. 2020 Dec 10. Abstract Super‐resolution optical fluctuation imaging (SOFI) is a super‐resolution microscopy technique that overcomes the diffraction limit by analyzing intensity fluctuations of statistically independent emitters in a time
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