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24.08.2019

Metal-induced energy transfer

Authors Gregor I, Chizhik A, Karedla N, Enderlein J Journal Nanophotonics Citation Nanophotonics, 8(10), 1689-1699. Abstract Since about a decade, metal-induced energy transfer (MIET) has become a tool to measure the distance of fluorophores to a metal-coated surface with nanometer accuracy. The energy transfer from a fluorescent molecule to surface
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20.08.2019

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

Authors Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT Journal Circulation Citation Circulation. 2019 Aug 20;140(8):681-693. Abstract
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01.08.2019

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau

Authors Brendel M, Deussing M, Blume T, Kaiser L, Probst F, Overhoff F, Peters F, von Ungern-Sternberg B, Ryazanov S, Leonov A, Griesinger C, Zwergal A, Levin J, Bartenstein P, Yakushev I, Cumming, P, Boening G, Ziegler S, Herms J, Giese A, Rominger A Journal Alzheimers’s Research and Therapy Citation
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22.07.2019

Molecular contribution function in RESOLFT nanoscopy

Authors Frahm L, Keller-Findeisen J, Alt P, Schnorrenberg S, Del Alamo Ruiz M, Aspelmeier T, Munk A, Jakobs S, Hell SW Journal Optics Express Citation Opt Express. 2019 Jul 22;27(15):21956-21987. Abstract BACKGROUND: The ultimate objective of a microscope of the highest resolution is to map the molecules of interest in
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16.07.2019

Modeling Fluorescence Correlation Spectroscopy through an aberrating sphere

Authors Ruhlandt D, Katti A, Derouard J, Delon A, Enderlein J Journal ArXiv Citation arXiv:1907.06907. Abstract Fluorescence Correlation Spectroscopy (FCS) is a powerful single-molecule technique which allows for measuring motion (diffusion, flow), concentration, and molecular interaction kinetics of fluorescent molecules from picomolar to micromolar concentrations. It has found manifold applications
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31.05.2019

Depopulation of dense alpha-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

Authors Wegrzynowicz, M.Bar-On D, Calo L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, Ashery U, Spillantini MG Journal Acta Neuropathologica Citation Acta Neuropathol. 2019 Oct;138(4):575-595. Abstract Parkinson’s disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies
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04.02.2019

High-resolution experimental and computational electrophysiology reveals weak beta-lactam binding events in the porin PorB

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs
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05.01.2019

A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice

Authors Al-Moyed H, Cepeda A P, Jung S, Moser T, Kugler S, Reisinger E Journal EMBO Molecular Medicine Citation EMBO Mol Med (2019) 11: e9396. Abstract Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene
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05.01.2019

Multiscale change-point segmentation: beyond step functions

Authors Li H, Guo Q, Munk A Journal Electronic Journal of Statistics Citation Electron. J. Statist. Volume 13, Number 2 (2019), 3254-3296. Abstract Modern multiscale type segmentation methods are known to detect multiple change-points with high statistical accuracy, while allowing for fast computation. Underpinning (minimax) estimation theory has been developed
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01.01.2019

Empirical optimal transport on countable metric spaces: Distributional limits and statistical applications

Authors Tameling C, Sommerfeld M, Munk A Journal Annals of Applied Probability Citation Ann. Appl. Probab. 29 (2019), no. 5, 2744–2781. Abstract We derive distributional limits for empirical transport distances between probability measures supported on countable sets. Our approach is based on sensitivity analysis of optimal values of infinite dimensional
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