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04.02.2019

High-resolution experimental and computational electrophysiology reveals weak beta-lactam binding events in the porin PorB

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs
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05.01.2019

A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice

Authors Al-Moyed H, Cepeda A P, Jung S, Moser T, Kugler S, Reisinger E Journal EMBO Molecular Medicine Citation EMBO Mol Med (2019) 11: e9396. Abstract Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene
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05.01.2019

Multiscale change-point segmentation: beyond step functions

Authors Li H, Guo Q, Munk A Journal Electronic Journal of Statistics Citation Electron. J. Statist. Volume 13, Number 2 (2019), 3254-3296. Abstract Modern multiscale type segmentation methods are known to detect multiple change-points with high statistical accuracy, while allowing for fast computation. Underpinning (minimax) estimation theory has been developed
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01.01.2019

Empirical optimal transport on countable metric spaces: Distributional limits and statistical applications

Authors Tameling C, Sommerfeld M, Munk A Journal Annals of Applied Probability Citation Ann. Appl. Probab. 29 (2019), no. 5, 2744–2781. Abstract We derive distributional limits for empirical transport distances between probability measures supported on countable sets. Our approach is based on sensitivity analysis of optimal values of infinite dimensional
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15.11.2018

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Authors Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF Journal Scientific Reports Citation Sci Rep. 2018
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05.02.2018

Anle138b modulates alpha-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

Authors Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N Journal Movement Disorders Citation Mov Disord. 2019 Feb;34(2):255-263. Abstract BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of alpha-synuclein
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