2022

Home >> Publications >> Release Date >> 2022 >> Seite 2
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06.12.2022

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation

Authors Voigt N, Maack C, Pronto JRD Journal Journal of the American College of Cardiology Citation J Am Coll Cardiol. 2022 Dec, 80 (23) 2220–2223. Abstract No abstract available DOI 10.1016/j.jacc.2022.09.043 Pubmed Link
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01.12.2022

Filter-based models of suppression in retinal ganglion cells: comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal BioRxiv Citation bioRxiv 2022.12.01.518577. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of the neural activity. Computational models of the interplay of excitation and suppression in
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29.11.2022

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

Authors Pinheiro Neto J, Spitzner FP, Priesemann V Journal PLoS Computational Biology Citation PLoS Comput Biol 18(11): e1010678. Abstract To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity
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24.11.2022

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.
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23.11.2022

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.
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21.11.2022

Structures of transcription preinitiation complex engaged with the +1 nucleosome

Authors Wang H, Schilbach S, Ninov M, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 21. Abstract The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed
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20.11.2022

Free-Breathing Myocardial T1 Mapping using Inversion-Recovery Radial FLASH and Motion-Resolved Model-Based Reconstruction

Authors Wang X, Rosenzweig S, Roeloffs V, Blumenthal M, Scholand N, Tan Z, Holme HCM, Unterberg-Buchwald C, Hinkel R, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2022 Nov 20. Abstract Purpose: To develop a free-breathing myocardial T1 mapping technique using inversion-recovery (IR) radial fast low-angle shot
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18.11.2022

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

Authors Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS Journal eLife Citation eLife 11:e79077. Abstract Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and
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16.11.2022

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum

Authors Schmidt J, Dreha-Kulaczewski S, Zafeiriou MP, Schreiber MK, Wilken B, Funke R, Neuhofer CM, Altmüller J, Thiele H, Nürnberg P, Biskup S, Li Y, Zimmermann WH, Kaulfuß S, Yigit G, Wollnik B. Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Nov 16;10:1025332. Abstract STAG2
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12.11.2022

Inflammation and vascular remodeling in COVID-19 hearts

Authors Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ,
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