Journal

Authors Ghosh A, Enderlein J Journal Current Opinion in Structural Biology Citation Curr Opin Struct Biol. 2021 Aug 6;70:123-131. Abstract We present the recent developments and advances in fluorescence correlation spectroscopy (FCS) and their application to the investigation of biomolecular conformations. In particular, we present and discuss three techniques: multichannel

Authors Zimmermann WH Journal Cardiovascular Research Citation Cardiovasc Res. 2021 Aug 4:cvab229. Abstract No Abstract available. DOI 10.1093/cvr/cvab229 Pubmed Link  

Authors Kulaitis G, Munk A, Werner F Journal The Annals of Statistic Citation Ann. Statist. 49(4): 2292-2312 (August 2021). Abstract As a general rule of thumb the resolution of a light microscope (i.e., the ability to discern objects) is predominantly described by the full width at half maximum (FWHM) of

Authors Sievers K, Welp L, Urlaub H, Ficner R Journal RNA Biology Citation RNA Biol. 2021 Jul 31:1-15. Abstract The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr. While both subunits of the functional heterodimer have been crystallized individually,

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Jul 27;55:102473. Abstract Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and

Authors Raad FS, Khan TA, Esser TU, Hudson JE, Seth BI, Fujita B, Gandamala R, Tietze LF, Zimmermann WH Journal EMBO Molecular Medicine Citation ChemMedChem. 2021 Jul 26. Abstract Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone

Authors Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2021

Authors Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, Cook A, Jurica M, Larsen NA, Pena V Journal Nature Communications Citation Nat Commun. 2021 Jul 23;12(1):4491. Abstract Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection

Authors Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN Journal Nature Communications Citation Nat Commun 12, 4466 (2021). Abstract Macrolides and ketolides comprise a family of clinically important antibiotics that

Authors Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2021 Jul 16. Abstract In conditions with abnormally increased activity of the cardiac ryanodine receptor (RyR2), Ca2+/calmodulin-dependent protein