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31.01.2022

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures

Authors Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G, Wollnik B Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 Jan 31:ddab373. Abstract Bloom syndrome (BS) is an autosomal recessive disease clinically characterized by primary microcephaly, growth deficiency, immunodeficiency, and
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27.01.2022

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Authors Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C Journal Nature Communications Citation Nat Commun. 2022 Jan 27;13(1):545. Abstract Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy
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27.01.2022

A Molecular Pump Facilitates Mechanical Adsorption Away from Equilibrium

Authors Simeth NA Journal Angewandte Chemie (International Edition) Citation Angew Chem Int Ed Engl. 2022 Jan 27:e202115145. Abstract Artificial molecular pumps that perform unidirectional motion on the molecular scale have been used to design systems operating away from equilibrium. Crafting such pumps onto a surface allows their unidirectional movement to
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26.01.2022

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III specific assembly factor in mitochondria

Authors Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacińska A Journal Molecular Biology of the Cell Citation Mol Biol Cell. 2022 Jan 26:mbcE21030143. Abstract Assembly of the dimeric complex III (CIII2) in the mitochondrial inner
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26.01.2022

Real-time radial tagging for quantification of left ventricular torsion

Authors Mohammadi E, Nasiraei-Moghaddam A, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2022 Jan 26. Abstract Purpose: To develop a real-time radial tagging MRI for accurate measurement of rotational motion and twist of the left ventricle (LV). Methods: A FLASH-based radial tagging sequence with an undersampled
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20.01.2022

On the Uniqueness of Kantorovich Potentials

Authors Staudt T, Hundrieser S, Munk A Journal arXiv Citation arXiv:2201.08316. Abstract Kantorovich potentials denote the dual solutions of the renowned optimal transportation problem. Uniqueness of these solutions is relevant from both a theoretical and an algorithmic point of view, and has recently emerged as a necessary condition for asymptotic
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19.01.2022

Molecular and functional architecture of striatal dopamine release sites

Authors Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen RL, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS Journal Neuron Citation Neuron. 2022 Jan 19;110(2):248-265.e9. Abstract Despite the importance of dopamine for striatal circuit function, mechanistic understanding
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14.01.2022

Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine

Authors Schoger E, Lelek S, Panáková D, Zelarayán LC Journal Frontiers in Cardiovascular Medicine Citation Front Cardiovasc Med. 2022 Jan 14;8:783072. Abstract Molecular and genetic differences between individual cells within tissues underlie cellular heterogeneities defining organ physiology and function in homeostasis as well as in disease states. Transcriptional control of
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13.01.2022

A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes

Authors Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis DA, Sanoudou D, Sacconi L, Hasenfuß G, Voigt N, Nikolaev VO, Lehnart SE Journal Journal of Molecular and Cellular Cardiology Citation J Mol Cell Cardiol. 2022 Jan 13;165:141-157.
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11.01.2022

The RNA methyltransferase METTL8 installs m3C32 modifications in mitochondrial tRNAThr/Ser(UCN) to optimise tRNA structure and translation

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial
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