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01.08.2025

Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system

Authors Jablonski L, Harczos T, Wolf B, Hoch G, Khurana L, Dieter A, Roos L, Hessler R, Ayub S, Ruther P, Moser T Journal Journal of Neural Engineering Citation J Neural Eng. 2025 Aug 1;22(4). Abstract Objective. In case of deafness, electrical cochlear implants (eCIs) bypass dysfunctional or lost hair
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28.07.2025

Efficient and sustained optogenetic control of sensory and cardiac systems

Authors Alekseev A, Hunniford V, Zerche M, Jeschke M, El May F, Vavakou A, Siegenthaler D, Hüser MA, Kiehn SM, Garrido-Charles A, Meyer A, Rambousky A, Alvanos T, Witzke I, Rojas-Garcia KD, Draband MD, Cyganek L, Klein E, Ruther P, Huet A, Trenholm S, Macé E, Kusch K, Bruegmann T,
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24.07.2025

Central limit theorems for the eigenvalues of graph Laplacians on data clouds

Authors Lui C, Trillos NG, Li H, Suchan L Journal Arxiv Citation arXiv:2507.18803. Abstract Given i.i.d.\ samples Xn={x1,…,xn} from a distribution supported on a low dimensional manifold M embedded in Eucliden space, we consider the graph Laplacian operator Δn associated to an ε-proximity graph over Xn and study the asymptotic
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22.07.2025

3D multiscale shape analysis of nuclei and in vivo elastic stress sensors allows force inference

Authors Jurado A, Isensee J, Hofemeier A, Krüger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Jul 22:S0006-3495(25)00450-3. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological
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22.07.2025

3D multiscale shape analysis of nuclei and in-vivo elastic stress sensors allows force inference

Authors Jurado A, Isensee J, Hofemeier A, Krüger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Jul 22:S0006-3495(25)00450-3. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological
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19.07.2025

Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin

Authors Imse B, Rojas L, Herrero CG, Thallmair S, Rhee JS, Simeth N Journal RSC Chemical Biology Citation RSC Chem Biol. 2025 Jul 19. Abstract Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules
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14.07.2025

Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy

Authors Yalçin M, Grande V, Outeiro TF, Relόgio A Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Jul 14;11(1):213. Abstract Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. This leads to hallmark motor features that include bradykinesia,
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12.07.2025

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal Nature Communications Citation Nat Commun. 2025 Jul 12;16(1):6450. Abstract Activity recognition in live-cell imaging is labor-intensive
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11.07.2025

Autonomous bioluminescence emission from transgenic mice

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal Science Advances Citation Sci Adv. 2025 Jul 11;11(28):eads0463. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells
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10.07.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are
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