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06.07.2023

ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts

Authors Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Smidova Molska E, Wu G, Schmid M, Bugai A, Jakobsen L, Zumer K, Cramer P, Andersen JS, Conti E, Jensen TH Journal Molecular Cell Citation Mol Cell. 2023 Jul 6;83(13):2240-2257.e6. Abstract The RNA-binding ARS2 protein is centrally
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05.07.2023

Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)

Authors Priesmeier L, Schoger E, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2023 Jul 5;71:103163. Abstract Towards increasing the possibility for temporal control of gene expression using CRISPR activation (a) systems, we generated homozygous human induced pluripotent stem cell (hiPSC) lines carrying a doxycycline (dox)-inducible
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02.07.2023

AI and protein structure and function in neurological disease: relevance to disease management

Authors Outeiro TF, Vieira TCRG Journal Nature Reviews. Neurology Citation Nat Rev Neurol. 2023 Jul 2. Abstract No abstract available. DOI 10.1038/s41582-023-00840-z   Pubmed Link  
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01.07.2023

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

Authors Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F   Journal Molecular Biology of the Cell   Citation Mol Biol Cell. 2023 Jul 1;34(8):ar81.   Abstract During embryonic development, dramatic cell shape changes and movements reshape the embryonic body plan.
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30.06.2023

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

Authors Baeuerlein FJB, Renner M, El Chami D, Lehnart SE, Pastor-Pareja JC, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to voluminous biological specimens such
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29.06.2023

Translation termination in human mitochondria – substrate specificity of mitochondrial release factors

Authors Nadler F, Richter-Dennerlein R Journal Biological Chemistry Citation Biol Chem. 2023 Jun 29. Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to
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29.06.2023

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Authors Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich
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29.06.2023

Mechanisms of inward transmembrane proton translocation

Authors Kovalev K, Tsybrov F, Alekseev A, Shevchenko V, Soloviov D, Siletsky S, Bourenkov G, Agthe M, Nikolova M, von Stetten D, Astashkin R, Bukhdruker S, Chizhov I, Royant A, Kuzmin A, Gushchin I, Rosselli R, Rodriguez-Valera F, Ilyinskiy N, Rogachev A, Borshchevskiy V, Schneider TR, Bamberg E, Gordeliy V
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28.06.2023

Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson’s disease

Authors Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jun 28. Abstract The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to
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28.06.2023

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Authors Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP Journal Chemical Reviews Citation Chem Rev. 2023 Jun 28. Abstract Biomolecular condensates, membrane-less entities arising from liquid-liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions,
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