2026 – Seite 7

12.02.2026

Two-photon voltage imaging with rhodopsin-based sensors

Authors Grimm C, Sims RR, Tanese D, Mohamed Lafirdeen AS, Bendifallah I, Chan CY, Faini G, Putti E, Del Bene F, Papagiakoumou E, Emiliani V Journal Neuron Citation Neuron. 2026 Feb 12:S0896-6273(25)00970-5. Abstract Advances in optical techniques and two-photon (2P) sensitive genetic voltage indicators (GEVIs) enabled in-depth voltage imaging at

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10.02.2026

Multi-scale transcriptomic integration reveals cell-type immune networks and lncRNA remodeling in Alzheimers disease

Authors Cortes Silva JA, Gertig M, Centeno TP, Burkhardt S, Schutz AL, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.02.08.704661. Abstract Alzheimers disease (AD) displays pronounced regional heterogeneity, yet how transcriptional changes across brain regions converge into coordinated cellular and molecular programs remains unclear. Here, we integrated bulk and

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03.02.2026

Mechanisms and disease relevance of mitochondrial translation in humans

Authors Richter-Dennerlein R, Dopico XC, Rorbach J Journal Nature Reviews. Molecular Cell Biology Citation Nat Rev Mol Cell Biol. 2026 Feb 13. Abstract Human mitochondrial ribosomes (mitoribosomes) synthesize the 13 mitochondrial-encoded proteins of the oxidative phosphorylation machinery in a coordinated manner, ensuring proper folding of nascent peptides into the inner

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25.01.2026

Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

Authors Haertter D, Hauke L, Driehorst T, Nish Ki, Zimmermann W, Schmidt CF Journal BioRxiv Citation bioRxiv 2024.05.28.596183. Abstract Cardiac contraction is driven by the collective action of cardiomyocytes, that contain parallel bundles of myofibrils consisting of linear chains of sarcomeres, the basic force-generating units. The dynamics of individual sarcomeres

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20.01.2026

Mapping Optical Chirality with Single Fluorescent Molecules

Authors Marx D, Gligonov I, Malsbenden D, Wöll D, Nevskyi O, Enderlein J. Journal Nano Letters Citation Nano Lett. 2026 Jan 20. Abstract Single fluorescent molecules, acting as ideal point dipoles, offer a unique means to probe light-matter interactions at the nanoscale. Here, we exploit this property to map the

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20.01.2026

Räumliche Organisation des Erbguts prägt Herzkrankheiten mit

In einer gemeinsamen Studie der DZHK-Standorte Heidelberg, München und Göttingen entschlüsseln Forschende, wie die räumliche Organisation des Genoms im Herzen genetische Krankheitsrisiken bestimmt. Die meisten genetischen Risikovarianten für Herzerkrankungen liegen außerhalb von Genen und wirken im Herzen nicht überall gleich. Warum sie gezielt zu Herzrhythmusstörungen oder zu einer Herzschwäche

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16.01.2026

DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue

Authors Häring M, Zhang Y, Zhang N, Allgeyer ES, Richens JH, Sirinakis G, Lv Z, St Johnston D, Wolf F, Großhans J, Kong D Journal Biophysical Journal Citation Biophys J. 2026 Jan 16:S0006-3495(26)00041-X. Abstract Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay

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13.01.2026

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Do TT, Schwenzer N, Petrovic A, Dresbach T, Lehnart SE, Fernández-Busnadiego R, Moser T Journal eLife Citation Elife. 2026 Jan 13;13:RP98254. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ)

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12.01.2026

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors Haydar S, Bednarz R, Laurette P, Sobitov I, Díaz I Pedrosa N, Videm P, Lueneburg T, Kuß S, Lahm H, Dreßen M, Krane M, Schmidt C, Grüning BA, Voigt N, Streckfuss-Bömeke K, Gilsbach R Journal Nature Communications Citation Nat Commun. 2026 Jan 12;17(1):117. Abstract Cis-regulatory elements (CREs) are noncoding

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12.01.2026

Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies

Authors Di Donato N; NMA Consortium; Thom A, Rump A, Greve JN, Cadiñanos J, Calabro S, Cathey S, Chung B, Cope H, Costales M, Cuvertino S, Dinkel P, Erripi K, Fry AE, Garavelli L, Hoffjan S, Janzarik WG, Kreimer I, Mancini G, Marin-Reina P, Meinhardt A, Niehaus I, Pilz D,

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