2020

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the

Authors Satija R, Das A, Mühle S, Enderlein J, Makarov DE Journal Journal of Physical Chemistry B Citation J Phys Chem B. 2020 Apr 30;124(17):3482-3493. Abstract We study intrachain dynamics of intrinsically disordered proteins, as manifested by the time scales of loop formation, using atomistic simulations, experiment-parametrized coarse-grained models, and

Authors Zimmermann WH Journal Current Opinion in Physiology Citation Current Opinion in Physiology 2020, 14:70–77. Abstract The lack of regenerative therapies for the treatment of degenerative diseases, such as heart failure, motivates the search for cell therapeutics. From a technical point of view, cell-based heart repair is approached from two

Authors Ragamin A, Yigit G, Bousset K, Beleggia F, Verheijen FW, de Wit MCY, Strom TM, Dörk T, Wollnik B, Mancini GMS Journal American Journal of Medical Genetics Part A Citation Am J Med Genet A. 2020 Jun;182(6):1378-1386. Abstract DNA double-strand breaks (DSBs) are highly toxic DNA lesions that can

Authors Joppe K, Nicolas JD, Grünewald TA, Eckermann M, Salditt T, Lingor P Journal Biomedical Optics Express Citation Biomed. Opt. Express. 2020 11(4). Abstract In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls.

Authors Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH Journal Cell Reports Citation Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. Abstract Purpose: Although similar in molecular composition, synapses can exhibit strikingly distinct functional transmitter release and plasticity characteristics. To determine

Authors Reichardt M, Frohn J, Khan A, Alves F, Salditt T Journal Biomedical Optics Express Citation Biomed Opt Express. 2020 May 1; 11(5): 2633–2651. Abstract The spatial organization of cardiac muscle tissue exhibits a complex structure on multiple length scales, from the sarcomeric unit to the whole organ. Here we

Authors Wagner FR, Dienemann C, Wang H, Stützer A, Tegunov D, Urlaub H, Cramer P Journal Nature Citation Nature 579, 448–451 (2020). Abstract Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs). In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC

Authors Reichardt M, Topperwien M, Khan A, Alves F, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Mar;7(2):023501. Abstract Purpose: We present a phase-contrast x-ray tomography study of wild type C57BL/6 mouse hearts as a nondestructive approach to the microanatomy on the scale of the

Authors Staudt T, Aspelmeier T, Laitenberger O, Geisler C, Egner A, Munk A Journal Statistical Science Citation Statist. Sci., Volume 35, Number 1 (2020), 92-111. Abstract Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units