Research Alliance

Authors Karschin N, Becker S, Griesinger C Journal Journal of the American Chemical Society Citation J Am Chem Soc. 2022 Sep 9. Abstract Paramagnetic NMR constraints are very useful to study protein interdomain motion, but their interpretation is not always straightforward. On the example of the particularly flexible complex Calmodulin/Munc13-1,

Authors Pinkert-Leetsch D, Rost JU, Schmiedeknecht MUH, Stadelmann C, Alves F, Missbach-Guentner J Journal Andrology Citation Andrology. 2022 Sep 8. Abstract Background: The unique anatomy of the male reproductive organ reflects its complex function from sperm maturation to their storage for months until emission. Since light microscopy in two dimensions

Authors Brás IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF Journal Journal of Proteomics Citation J Proteomics. 2022 Sep 8:104721. Abstract Extracellular vesicles (EVs) are important mediators in intercellular communication. However, understanding the biological origin and functional effects of EVs

Authors Brandenburg S, Otto L, Schönberger HL, Jacob CF, Paulke NJ, Beuthner BE, Topci R, Kohl T, Neuenroth L, Kutschka I, Urlaub H, Kück F, Leha A, Friede T, Seidler T, Jacobshagen C, Toischer K, Puls M, Hasenfuß G, Lenz C, Lehnart SE Journal Journal of Molecular and Cellular Cardiology

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure

Authors Charalambous C, Webster A, Schuh M Journal Nature Reviews Molecular Cell Biology Citation Nat Rev Mol Cell Biol. 2022 Sep 6. Abstract During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo. However, human eggs frequently contain an incorrect

Authors Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S Journal Nature Methods Citation Nat Methods (2022). Abstract MINimal fluorescence photon FLUXes (MINFLUX) nanoscopy, providing photon-efficient fluorophore localizations, has brought about three-dimensional resolution at nanometer scales. However, by using an intrinsic on–off switching

Authors Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U Journal Molecular Cell Citation Mol Cell. 2022 Sep 1;82(17):3226-3238.e7. Abstract Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved yeast protein, Get3, switches

Authors Lorenz C, Köster S Journal Biophysics Reviews Citation Biophysics Rev. 3, 031304 (2022) Abstract Different types of biological cells respond differently to mechanical stresses, and these responses are mainly governed by the cytoskeleton. The main components of this biopolymer network are actin filaments, microtubules, and intermediate filaments, whose mechanical

Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the