Targeting of Membrane Proteins

Authors Banerjee S, Simonetti FL, Detrois KE, Kaphle A, Mitra R, Nagial R, Söding J Journal Genome Biology Citation Genome Biol. 2021 May 6;22(1):142. Abstract Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs

Authors Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R Journal Structure Citation Structure 2021 Apr 26:S0969-2126(21)00119-2 (in press). Abstract The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington’s

Authors Baeuerlein FJB, Pastor-Pareja JC, Fernandez-Busnadiego R Journal bioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to tissues, as they usually require high-pressure freezing for vitrification. Here we

Authors Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R Journal Nature Communications Citation Nat Commun 12, 2110 (2021). Abstract The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were

Authors Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2021 Apr 12;14:659926. Abstract Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative

Authors Seefelder M, Alva V, Huang B, Engler T, Baumeister W, Guo Q, Fernández-Busnadiego R, Lupas AN, Kochanek S Journal BMC Evolutionary Biology Citation BMC Evol Biol. 2020 Dec 9;20(1):162. Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease

Authors Bäuerlein FJB, Fernandez-Busnadiego R, Baumeister W Journal Trends in Cell Biology Citation Trends Cell Biol. 2020 Dec;30(12):951-966. Abstract Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still

Authors Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2020 Oct 2;21(19):E7298. Abstract Synapses play a central role for the processing of information in the brain and have been analyzed in countless biochemical, electrophysiological, imaging, and computational

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a

Authors Bonnin EA, Rizzoli SO Journal Frontiers in Behavioral Neuroscience Citation Front Behav Neurosci. 2020 Jul 20;14:124. Abstract The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically