Assembly and Function of Ion Channel Clusters

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Seeded Binary Segmentation: A general methodology for fast andoptimal change point detection

Authors Kovács S, Li H, Bühlmann P, Munk A Journal Biometrika Citation Biometrika, 2022, asac052. Abstract We propose seeded binary segmentation for large scale changepoint detection problems. We construct a deterministic set of background intervals, called seeded intervals, in which single changepoint candidates are searched for. The final selection of
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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Authors Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE Journal Science Reports Citation Sci Rep. 2022 Jun 20;12(1):10387. Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific
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Synaptic transmission at the vestibular hair cells of amniotes

Authors Mukhopadhyay M, Pangrsic T Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2022 Jun 3;121:103749. Abstract A harmonized interplay between the central nervous system and the five peripheral end organs is how the vestibular system helps organisms feel a sense of balance and motion in three-dimensional space. The
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The Role of Junctophilin Proteins in Cellular Function

Authors Lehnart SE, Wehrens XHT Journal Physiological Reviews Citation Physiol Rev. 2022 Jan 10. Abstract Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum. Tethering of these membrane structures results in the formation of highly organized subcellular junctions
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Instant three-color multiplane fluorescence microscopy

Authors Gregor I, Butkevich E, Enderlein J, Mojiri S Journal Biophysical Reports Citation Biophysical Reports 1 (1), 8 Sep 2021, 100001. Abstract One of the most widely used microscopy techniques in biology and medicine is fluorescence microscopy, offering high specificity in labeling as well as maximal sensitivity. For live-cell imaging,
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The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1

Authors Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK Journal Physiological Reports Citation Physiol Rep. 2021 Sep;9(18):e15030. Abstract Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β-adrenoceptor stimulation-induced
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isoSTED microscopy with water-immersion lenses and background reduction

Authors Siegmund R, Werner F, Jakobs S, Geisler C, Egner A Journal Biophysical Journal Citation Biophys J. 2021 Jul 8:S0006-3495(21)00556-7. Abstract Fluorescence microscopy is an excellent tool to gain knowledge on cellular structures and biochemical processes. Stimulated emission depletion (STED) microscopy provides a resolution in the range of a few
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Drosophila Mechanosensory Transduction

Authors Hehlert P, Zhang W, Göpfert MC Journal Trends in Neurosciences Citation Trends Neurosci. 2020 Nov 27:S0166-2236(20)30251-4. Abstract Mechanosensation in Drosophila relies on sensory neurons transducing mechanical stimuli into ionic currents. The molecular mechanisms of this transduction are in the process of being revealed. Transduction relies on mechanogated ion channels
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Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

Authors Jean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D, Kroll J, Nardis C, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T Journal Nature Communications Citation Nat Comm. 2020 Jun 25;11(1):3208. Abstract Inner hair cells (IHCs) are the primary receptors for hearing.
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Tomographic STED microscopy

Authors Krüger JR, Keller-Findeisen J, Geisler C, Egner A Journal Biomedical Optics Express Citation Biomed. Opt. Express 11, 3139-3163 (2020). Abstract Stimulated emission depletion (STED) microscopy is a versatile imaging method with diffraction-unlimited resolution. Here, we present a novel STED microscopy variant that achieves either increased resolution at equal laser
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