Release Date

Authors Outeiro TF, Heutink P, Bezard E, Cenci AM Journal Movement Disorders Citation Mov Disord. 2020 Nov 16. Abstract Parkinson’s disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely

Authors Dominguez-Meijide A, Vasili E, Outeiro TF Journal Brain Science Citation Brain Sci. 2020 Nov 13;10(11):E858. Abstract Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.

Authors del Alamo M, Li H, Munk A, Werner F Journal Algorithms Citation Algorithms 2020, 13(11), 296. Abstract Many modern statistically efficient methods come with tremendous computational challenges, often leading to large-scale optimisation problems. In this work, we examine such computational issues for recently developed estimation methods in nonparametric regression

Authors Maier O, Baete SH, Fyrdahl A, Hammernik K, Harrevelt S, Kasper L, Karakuzu A, Loecher M, Patzig F, Tian Y, Wang K, Gallichan D, Uecker M, Knoll F Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2020 Nov 12. Abstract Purpose: The aim of this work is to

Authors Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK Journal Elife Citation Elife. 2020 Nov 9;9:e62506. Abstract Insulin

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular

Authors Tomsits P, Schüttler D, Kääb S, Clauss S, Voigt N Journal Journal of Visualized Experiments Citation J Vis Exp. 2020 Nov 3;(165). Abstract Mouse models play a crucial role in arrhythmia research and allow studying key mechanisms of arrhythmogenesis including altered ion channel function and calcium handling. For this

Authors Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H Journal Genetics Citation Genetics. 2020 Nov;216(3):735-752. Abstract Sleep is a conserved behavioral state. Invertebrates typically show quiet sleep, whereas in mammals, sleep consists of periods of nonrapid-eye-movement sleep (NREMS) and REM

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore

Authors Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, Deckers M, Rehling P Journal FEBS Letters Citation FEBS Lett. 2020 Oct 30. Abstract The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The Translocase of the Inner