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22.03.2025

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity

Authors Lin KH, Ranjan M, Lipstein N, Brose N, Neher E, Taschenberger H Journal The Journal of Physiology Citation J Physiol. 2025 Mar 22. Abstract Heterogeneity in synaptic strength and short-term plasticity (STP) was characterized in post-hearing rat calyx of Held synapses at near-physiological external [Ca2+] under control conditions and
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21.03.2025

In situ architecture of the human prohibitin complex

Authors Lange F, Ratz M, Dohrke JN, Wenzel D, Ilgen P, Riedel D, Jakobs S Journal Nature Cell Biology Citation Nat Cell Biol (2025). Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle
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18.03.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025; 15(10):4270-4286. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept
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13.03.2025

Ca2+-triggered (de)ubiquitination events in synapses

Authors Ainatzi S, Kaufmann SV, Silbern I, Georgiev SV, Lorenz S, Rizzoli SO, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2025 Mar 13:100946. Abstract Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation
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13.03.2025

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez S, Klein R, Giese A, Griesinger C, Dudanova I Journal BioRxiv Citation bioRxiv 2025.03.11.642540. Abstract Huntington′s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is
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10.03.2025

Leaflet-specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers

Authors Karedla N, Schneider F, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Mar 10:e202423784. Abstract Polymer-supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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07.03.2025

Optimal and fast online change point estimation in linear regression

Authors Hüselitz A, Li H, Munk A Journal Arxiv Citation arXiv:2503.05270. Abstract We consider the problem of sequential estimation of a single change point in a piecewise linear regression model under a Gaussian setup. We demonstrate that a certain CUSUM-type statistic attains the minimax optimal rates for localizing the change
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06.03.2025

Structural basis of Nipah virus RNA synthesis

Authors Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Journal Nature Communications Citation Nat Commun. 2025 Mar 6;16(1):2261. Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its
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05.03.2025

A general framework for interpretable neural learning based on local information-theoretic goal functions

Authors Makkeh A, Graetz M, Schneider AC, Ehrlich DA, Priesemann V, Wibral M Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2408125122. Abstract Despite the impressive performance of biological and artificial networks, an intuitive
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