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16.06.2025

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Tirincsi A, Vukusic K, Mohseni F, Wardenaar R, Losito M, Goenenc II, Wollnik B, Foijer F, Tolic IM, Storchova Z, Raschle M Journal BioRxiv Citation bioRxiv 2025.06.16.659902. Abstract The BLM helicase is a critical genome maintenance protein involved in diverse cellular processes including DNA replication,
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12.06.2025

Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure

Authors Gisa V, Islam MR, Lbik D, Hofmann RM, Pena T, Krüger DM, Burkhardt S, Schütz AL, Sananbenesi F, Toischer K, Fischer A Journal Non-coding RNA Citation Noncoding RNA. 2025 Jun 12;11(3):45. Abstract Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet
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11.06.2025

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors Harris SS, Rajani RM, Zünkler J, Ellingford R, Yang M, Rowland JM, Schmidt A, Lee BI, Kehring M, Hellmuth M, Lam FKW, Fässler D, Erdinger S, Wolfer DP, Sala Frigerio C, Wolf F, Hyman BT, Müller UC, Busche MA Journal Cell Reports Citation Cell Rep. 2025 Jun 11;44(6):115801. Abstract
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10.06.2025

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Authors Solomon P, Budde M, Kohshour MO, Adorja K, Heilbronner M, Navarro-Flores A, Papiol S, Reich-Erkelenz D, Schulte EC, Senner F, Vogl T, Kaurani L, Krüger DM, Sananbenesi F, Pena T, Burkhardt S, Schütz AL, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Juckel
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10.06.2025

Dual effect of alpha-synuclein disease variants on condensate formation

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent
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03.06.2025

NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer’s disease

Authors Pradhan R, Petrovic Z, Sakib MS, Schroeder S, Krueger DM, Pena T, Diniz E, Burkhardt S, Schuetz AL, Grządzielewska I, Toischer K, Stein TD, Blusztajn JK, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.06.01.657217. Abstract The increasing evidence that non-coding RNAs can become deregulated
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03.06.2025

Learning to cluster neuronal function

Authors Nellen NS, Turishcheva P, Vystrčilová M, Sridhar S, Gollisch T, Tolias AS, Ecker AS Journal Arxiv Citation arXiv:2506.03293. Abstract Deep neural networks trained to predict neural activity from visual input and behaviour have shown great potential to serve as digital twins of the visual cortex. Per-neuron embeddings derived from
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01.06.2025

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Authors Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schröder GF, Andreas LB, Griesinger C Journal Nature Communication Citation Nat Commun. 2025 Oct 3;16(1):8850. Abstract Alzheimer’s disease
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29.05.2025

Detection and inference of changes in high-dimensional linear regression with non-sparse structures

Authors Cho H, Kley T, Li H Journal Journal of the Royal Statistical Society, Series B Citation Journal of the Royal Statistical Society Series B: Statistical Methodology, Volume 87, Issue 5, November 2025, Pages 1528–1552. Abstract For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed
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28.05.2025

Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors

Authors Kloskowski P, Neumann P, Kumar P, Berndt A, Dobbelstein M, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Crystallogr D Struct Biol. 2025 Jun 1. Abstract The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target
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