2024

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23.09.2024

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Authors Bharti A, Ajinkya K, Andrea MM, Ramos-Gomes F, Bohnenberger H, Ströbel P, Alves F, Klein O Journal npj Imaging Citation npj Imaging 2, 35 (2024). Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, accentuated by its heterogeneity and complex tumour microenvironment (TME). The role of
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19.09.2024

Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT

Authors Engeholm M, Roske JJ, Oberbeckmann E, Dienemann C, Lidschreiber M, Cramer P, Farnung L Journal Molecular Cell Citation Mol Cell. 2024 Sep 19;84(18):3423-3437.e8. Abstract To maintain the nucleosome organization of transcribed genes, ATP-dependent chromatin remodelers collaborate with histone chaperones. Here, we show that at the 5′ ends of yeast
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18.09.2024

The plasma miRNAome in ADNI: signatures to aid the detection of at-risk individuals

Authors Krüger MD, Pena-Centeno T, Lui S, Park T, Kaurani L, Pradhan R, Huang YN, Risacher S, Burkhardt S, Schütz AL, Wang Y, Shaw LM, Brodsky A, DeStefano AL, Lin H, Schroeder R, Krunic A, Hempel N, Sananbenesi F, Blusztajn JK, Saykin AJ, Delalle I, Nho K, Fischer A Journal
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18.09.2024

Plasma miRNAs across the Alzheimer’s disease continuum: Relationship to central biomarkers

Authors Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K; Alzheimer’s Disease Neuroimaging Initiative Journal
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18.09.2024

Volumetric changes of the enteric nervous system under physiological and pathological conditions measured using x-ray phase-contrast tomography

Authors Peruzzi N, Eckermann M, Frohn J, Salditt T, Ohlsson B, Bech M Journal JGH Open Citation JGH Open. 2024 Sep 18;8(9):e70027. Abstract Background and Aim: Full-thickness biopsies of the intestinal wall may be used to study and assess damage to the neurons of the enteric nervous system (ENS), that
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17.09.2024

Multiplex Microscopy Assay for Assessment of Therapeutic and Serum Antibodies against Emerging Pathogens

Authors Sartingen N, Stürmer V, Kaltenböck M, Müller TG, Schnitzler P, Kreshuk A, Kräusslich HG, Merle U, Mücksch F, Müller B, Pape C, Laketa V Journal Viruses Citation Viruses 2024, 16(9), 1473. Abstract The emergence of novel pathogens, exemplified recently by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights
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17.09.2024

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

Authors Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, Brose N, Taschenberger H, Krueger-Burg D Journal Communications Biology Citation Commun Biol. 2024 Sep 17;7(1):1157. Abstract Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all
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13.09.2024

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Authors Naas J, Nies G, Li H, Stoldt S, Schmitzer B, Jakobs S, Munk A Journal Communications Biology Citation Commun Biol 7, 1139 (2024). Abstract With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate
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12.09.2024

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.09.12.612649. Abstract N6-methyladenosine (m6A) is the most abundant and conserved transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A in the development of
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10.09.2024

KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Authors Tapia Contreras C, Falke JD, Seifert DM, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi
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