2023

Authors Hoffmann C, Rentsch J, Tsunoyama TA, Chhabra A, Aguilar Perez G, Chowdhury R, Trnka F, Korobeinikov AA, Shaib AH, Ganzella M, Giannone G, Rizzoli SO, Kusumi A, Ewers H, Milovanovic D Journal Nature Communications Citation Nat Commun. 2023 Oct 23;14(1):6730. Abstract Neuronal transmission relies on the regulated secretion of

Authors Rölleke U, Kumari P, Meyer R, Köster S Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2023 Oct 21;85:102263. Abstract Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the eukaryotic cytoskeleton and each of the three filament types contributes very distinct mechanical properties to

Authors Vieira TCRG, Barros CA, Domingues R, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2023 Oct 19. Abstract The discovery of prions has challenged dogmas and has revolutionized our understanding of protein-misfolding diseases. The concept of self-propagation via protein conformational changes, originally discovered for the prion protein (PrP),

Authors Socrier L, Sharma A, Chen T, Flato K, Kettelhoit K, Enderlein J, Werz DB, Steinem C Journal Biophysical Journal Citation Biophys J. 2023 Oct 17;122(20):4104-4112. Abstract Fluorescent lipid probes are an invaluable tool for investigating lipid membranes. In particular, localizing certain receptor lipids such as glycosphingolipids within phase-separated membranes

Authors Engelken R, Wolf F, Abbott LF Journal Physical Review Research Citation Phys. Rev. Research 5, 043044. Abstract Recurrent networks are widely used as models of biological neural circuits and in artificial intelligence applications. Mean-field theory has been used to uncover key properties of recurrent network models such as the

Authors Yao S, Zhou X, Gu M, Zhang C, Bartsch O, Vona B, Fan L, Ma L, Pan Y Journal Human Genomics Citation Hum Genomics. 2023 Oct 13;17(1):93. Abstract Background: Tooth agenesis is a common dental anomaly that can substantially affect both the ability to chew and the esthetic appearance

Authors Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2023 Oct 13;7(1):e202302030. Abstract Calcium (Ca2+) is a well-known second messenger in all cells, and is especially relevant for neuronal activity. Neuronal Ca2+ is found in different forms, with a minority

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly

Authors Mémoli F, Munk A, Wan Z, Weitkamp C Journal Discrete & Computational Geometry Citation Discrete Comput Geom (2023) Abstract We investigate compact ultrametric measure spaces which form a subset Uw of the collection of all metric measure spaces Mw. In analogy with the notion of the ultrametric Gromov–Hausdorff distance

Authors Moser T, Karagulyan N, Neef J, Jaime Tobon LM Journal EMBO Journal Citation EMBO J. 2023.e114587. Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal