2023

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29.12.2023

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although
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28.12.2023

SparseProp: Efficient Event-Based Simulation and Training of Sparse Recurrent Spiking Neural Networks

Authors Engelken R Journal Arxiv Citation arXiv:2312.17216. Abstract Spiking Neural Networks (SNNs) are biologically-inspired models that are capable of processing information in streams of action potentials. However, simulating and training SNNs is computationally expensive due to the need to solve large systems of coupled differential equations. In this paper, we
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28.12.2023

Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis

Authors Galbusera R, Bahn E, Weigel M, Cagol A, Lu PJ, Schaedelin SA, Franz J, Barakovic M, Rahmanzadeh R, Dechent P, Nair G, Brück W, Kuhle J, Kappos L, Stadelmann C, Granziera C Journal Neurology Citation Neurology. 2024 Feb 13;102(3):e207966. Abstract Background and Objectives: A subgroup of patients with multiple
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27.12.2023

Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase

Authors Sievers K, Neumann P, Sušac L, Da Vela S, Graewert M, Trowitzsch S, Svergun D, Tampé R, Ficner R Journal Structure Citation Structure. 2023 Dec 27:S0969-2126(23)00447-1. Abstract Eukaryotic tRNA guanine transglycosylase (TGT) is an RNA-modifying enzyme which catalyzes the base exchange of the genetically encoded guanine 34 of tRNAsAsp,Asn,His,Tyr
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27.12.2023

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses

Authors Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos
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21.12.2023

Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells

Authors Schreiber MK, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res, 21 December 2023, 103295. Abstract Human brain organoids can serve as models to study myelination, a process orchestrated by oligodendrocytes. Real-time imaging provides new insights on the communication of oligodendrocytes with neurons as well as demyelination processes
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21.12.2023

Visualization of deglutition and gastroesophageal reflux using real-time MRI: a standardized approach to image acquisition and assessment

Authors Biggemann L, Uhlig J, Streit U, Al-Bourini O, Wedi E, Amanzada A, Ellenrieder V, Rühlmann F, Ghadimi M, Frahm J, Uecker M, Seif Amir Hosseini A Journal Science Reports Citation Sci Rep. 2023 Dec 21;13(1):22854. Abstract This study aims to develop a standardized algorithm for gastroesophageal image acquisition and
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20.12.2023

Protocol to develop force-generating human skeletal muscle organoids

Authors Shahriyari M, Rinn M, Hofemeier AD, Babych A, Zimmermann WH, Tiburcy M Journal Star Protocols Citation STAR Protoc. 2023 Dec 20;5(1):102794. Abstract Force generation is an essential property of skeletal muscle models in vitro. We describe a versatile 1-step procedure to direct undifferentiated human pluripotent stem cells (PSCs) into
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19.12.2023

GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners

Authors Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 19:gkad1202. Abstract Regulation of RNA helicase activity, often accomplished by protein cofactors, is
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19.12.2023

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell

Authors Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2023 Dec 19:100704. Abstract In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory
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