2023

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27.01.2023

Cholesterol-Induced Nanoscale Variations in the Thickness of Phospholipid Membranes

Authors Chen T, Ghosh A, Enderlein J Journal Nano Letters Citation Nano Lett. 2023 Jan 27. Abstract Graphene-induced energy transfer (GIET) is a recently developed fluorescence-spectroscopic technique that achieves subnanometric optical localization of fluorophores along the optical axis of a microscope. GIET is based on the near-field energy transfer from
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23.01.2023

Towards Unbiased Fluorophore Counting in Superresolution Fluorescence Microscopy

Authors Laitenberger O, Aspelmeier T, Staudt T, Geisler C, Munk A, Egner A Journal Nanomaterials Citation Nanomaterials 2023, 13(3), 459. Abstract With the advent of fluorescence superresolution microscopy, nano-sized structures can be imaged with a previously unprecedented accuracy. Therefore, it is rapidly gaining importance as an analytical tool in the
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23.01.2023

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Authors Hunniford V, Kühler R, Wolf B, Keppeler D, Strenzke N, Moser T Journal Frontiers in Neuroscience Citation Front. Neurosci. 17:1105562. Abstract Background The electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency coding with
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21.01.2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Authors Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC Journal Communications Biology Citation Commun Biol. 2023 Jan 21;6(1):79. Abstract Aberrant Wnt activation has been reported in failing
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19.01.2023

Graded optogenetic activation of the auditory pathway for hearing restoration

Authors Mittring A, Moser T, Huet AT Journal Brain Stimulation Citation Brain Stimul. 2023 Jan 23:S1935-861X(23)01673-X. Abstract Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of
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10.01.2023

Translation Factor Accelerating Peptide Bond Formation on the Ribosome: EF-P and eIF5A as Entropic Catalysts and a Potential Drug Targets

Authors Mudryi V, Peske F, Rodnina M Journal BBA Advances Citation BBA Advances (2023). Abstract Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary translation factors that facilitate peptide bond formation when several sequential proline (Pro) residues are incorporated into the nascent chain. EF-P and eIF5A bind to
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10.01.2023

Trafficking proteins show limited differences in mobility across different postsynaptic spines

Authors Mougios N, Opazo F, Rizzoli SO, Reshetniak S Journal iScience Citation iScience (2023). Abstract The function of the postsynaptic compartment is based on the presence and activity of postsynaptic receptors, whose dynamics are controlled by numerous scaffolding, signaling and trafficking proteins. While the receptors and the scaffolding proteins have
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10.01.2023

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez O, Hammer E, Steinegger M, Böhmer L, Schroeder H, Kleinsorge M, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal BioRxiv Citation bioRxiv 2023.01.10.523203. Abstract Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset
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10.01.2023

Natural stimuli drive concerted nonlinear responses in populations of retinal ganglion cells

Authors Karamanlis D, Khani MH, Schreyer HM, Zapp SJ, Mietsch M, Gollisch T Journal BioRxiv Citation bioRxiv 2023.01.10.523412. Abstract The role of the vertebrate retina in early vision is generally described by the efficient coding theory, which predicts that the retina discards spatiotemporal correlations in natural scenes. It is unclear,
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09.01.2023

Age-dependent structural reorganization of utricular ribbon synapses

Authors Wichmann C, Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO Journal BioRxiv Citation bioRxiv 2022.12.19.521049. Abstract In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the
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