2023

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15.12.2023

Implications for neutrophils in cardiac arrhythmias

Authors Hegemann N, Barth L, Doering Y, Voigt N, Grune J Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2023 Dec 15. Abstract Cardiac arrhythmias commonly occur as a result of aberrant electrical impulse formation or conduction in the myocardium. Frequently discussed
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12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
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11.12.2023

Protein nanobarcodes enable single-step multiplexed fluorescence imaging

Authors de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO Journal PLoS Biology Citation PLoS Biol. 2023 Dec 11;21(12):e3002427. Abstract Multiplexed cellular imaging typically relies on the sequential application of detection probes, as antibodies or DNA
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08.12.2023

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

Authors Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C Journal iScience Citation iScience. 2023 Dec 8;27(1):108700. Abstract Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand
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08.12.2023

Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Authors Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T Journal Protein & Cell Citation Protein & Cell. 2023 Dec 8:pwad058. accepted manuscript.
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07.12.2023

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Authors Kyriakopoulou E, Versteeg D, de Ruiter H, Perini I, Seibertz F, Döring Y, Zentilin L, Tsui H, van Kampen S, Tiburcy M, Meyer T, Voigt N, van Tintelen J, Zimmermann W, Giacca M, van Rooij E Journal Nature Cardiovascular Research Citation Nat Cardiovasc Res 2, 1262–1276 (2023 Dec 07)
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07.12.2023

Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing

Authors Schreiber MK, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2023 Dec 7;74:103276. Abstract Genetic alterations in the PLP1 gene, i.e. point mutations and duplications, are associated with demyelinating disease Pelizaeus-Merzbacher. Here, we describe the generation of a human iPSC line harboring a PLP1 variant in codon
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05.12.2023

Evaluation of MR-safe bioptomes for MR-guided endomyocardial biopsy in minipigs: a potential radiation-free clinical approach

Authors Svetlove A, Ritter CO, Dullin C, Schmid M, Schauer S, Uihlein J, Uecker M, Mietsch M, Stadelmann C, Lotz J, Unterberg-Buchwald C Journal European Radiology Experimental Citation Eur Radiol Exp. 2023 Dec 5;7(1):76. Abstract Background: Diagnostic accuracy of endomyocardial biopsy could improve if clinically safe magnetic resonance (MR)-compatible bioptomes
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05.12.2023

The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro

Authors Wicke D, Neumann P, Gößringer M, Chernev A, Davydov S, Poehlein A, Daniel R, Urlaub H, Hartmann RK, Ficner R, Stülke J Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 5:gkad1171. Abstract Even though Bacillus subtilis is one of the most studied organisms, no function has been
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30.11.2023

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Authors Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A,
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