2023

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15.03.2023

Defective COX1 expression in aging mice liver

Authors Witte S, Boshnakovska A, Özdemir M, Chowdhury A, Rehling P, Aich A   Journal Biology Open   Citation Biol Open. 2023 Mar 15;12(3):bio059844.   Abstract Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild
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13.03.2023

Bayesian MRI reconstruction with joint uncertainty estimation using diffusion models

Authors Luo G, Blumenthal M, Heide M, Uecker M   Journal Magnetic Resonance in Medicine   Citation Magn Reson Med. 2023 Mar 13.   Abstract Purpose: We introduce a framework that enables efficient sampling from learned probability distributions for MRI reconstruction. Method: Samples are drawn from the posterior distribution given
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09.03.2023

Excitation Intensity-Dependent Quantum Yield of Semiconductor Nanocrystals

Authors Ghosh S, Ross U, Chizhik AM, Kuo Y, Jeong BG, Bae WK, Park K, Li J, Oron D, Weiss S, Enderlein J, Chizhik AI Journal The Journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2023 Mar 9:2702-2707. Abstract One of the key phenomena that determine the fluorescence
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08.03.2023

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies

Authors Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank
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08.03.2023

Bioinspired Membrane Interfaces: Controlling Actomyosin Architecture and Contractility

Authors Liebe NL, Mey I, Vuong L, Shikho F, Geil B, Janshoff A, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11586-11598. Abstract The creation of biologically inspired artificial lipid bilayers on planar supports provides a unique platform to study membrane-confined processes in
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06.03.2023

Uncovering the molecular link between lead toxicity and Parkinson’s disease

Authors Shvachiy L, Geraldes V, Outeiro TF Journal Antioxidants & Redox Signaling Citation Antioxid. Redox Signal. 39, 321–335. Abstract Significance: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and occupational exposures to heavy metals are likely
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06.03.2023

Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V   Journal Cells   Citation Cells. 2023 Mar 6;12(5):818.   Abstract The nervous system is the primary target for lead exposure and the developing brain appears to be especially susceptible, namely the hippocampus. The mechanisms of lead neurotoxicity remain
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02.03.2023

A small-angle X-ray scattering study of red blood cells in continuous flow

Authors Burchert JP, Graceffa R, Saldanha O, Burghammer M, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2023 May 1. Abstract Owing to their large penetration depth and high resolution, X-rays are ideally suited to study structures and structural changes within intact biological cells. For this reason,
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28.02.2023

In vitro reconstitution of chromatin domains

Authors Quililan K, Oberbeckmann E, Cramer P, Oudelaar AM   Journal BioRxiv   Citation bioRxiv 2023.02.27.530214.   Abstract The spatial organization of the genome modulates nuclear processes, including transcription, replication, and DNA repair1,2. Eukaryotic genomes are organized into distinct 3D chromatin domains3. However, the molecular mechanisms that drive the formation
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28.02.2023

The multifaceted mitochondrial OXA insertase

Authors Homberg B, Rehling P, Cruz-Zaragoza LD Journal Trends in Cell Biology Citation Trends Cell Biol. 2023 Feb 28:S0962-8924(23)00020-X. Abstract Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are
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