2022

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15.04.2022

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Authors Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Qiu T, Kathayat RS, Dickinson BC, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R Journal Science Advances Citation Sci Adv. 2022 Apr 15;8(15):eabj8633. Abstract Genetic CLN5 variants are associated
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13.04.2022

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Authors Vincenti I, Page N, Steinbach K, Yermanos A, Lemeille S, Nunez N, Kreutzfeldt M, Klimek B, Di Liberto G, Egervari K, Piccinno M, Shammas G, Mariotte A, Fonta N, Liaudet N, Shlesinger D, Liuzzi AR, Wagner I, Saadi C, Stadelmann C, Reddy S, Becher B, Merkler D Journal Science
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11.04.2022

Retinal receptive-field substructure: scaffolding for coding and computation

Authors Zapp SJ, Nitsche S, Gollisch T Journal Trends in Neurosciences Citation Trends Neurosci. 2022 Apr 11:S0166-2236(22)00056-X. Abstract The center-surround receptive field of retinal ganglion cells represents a fundamental concept for how the retina processes and encodes visual information. Yet, traditional approaches of using the receptive field as a linear
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07.04.2022

Rapidly Signal-enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance

Authors Ding Y, Korchak S, Mamone S, Jagtap AP, Stevanato G, Sternkopf S, Moll D, Schroeder H, Becker S, Fischer A, Gerhardt E, Outeiro TF, Opazo F, Griesinger C, Glöggler S Journal Chemistry Methods Citation Chem. Methods 2022, e202200023. Abstract Nuclear magnetic resonance (NMR) is widely applied from analytics to
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04.04.2022

Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation – A proof-of-concept study

Authors Jebran AF, Tiburcy M, Biermann D, Balfanz P, Didié M, Karikkineth BC, Schöndube F, Kutschka I, Zimmermann WH Journal Journal of Molecular and Cellular Cardiology Citation J Mol Cell Cardiol. 2022 Apr 4;168:3-12. Abstract Engineered heart muscle (EHM) can be implanted epicardially to remuscularize the failing heart. In case
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04.04.2022

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

Authors Peña-Díaz S, Pujols J, Vasili E, Pinheiro F, Santos J, Manglano-Artuñedo Z, Outeiro TF, Ventura S Journal Journal of Biological Chemistry Citation J Biol Chem. 2022 Apr 4;298(5):101902. Abstract Parkinson’s disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as
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01.04.2022

Optimal transfer functions for bandwidth-limited imaging

Authors Stallinga S, Radmacher N, Delon A, Enderlein J Journal Physical Review Research Citation Phys. Rev. Research 4, 023003. Abstract One of the fundamental limits of classical optical microscopy is the diffraction limit of optical resolution. It results from the finite bandwidth of the optical transfer function (or OTF) of
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01.04.2022

Selective optogenetic control of Gq signaling using human Neuropsin

Authors Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T Journal Nature Communications Citation Nat Commun. 2022 Apr 1;13(1):1765. Author Correction: Nat Commun.
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31.03.2022

Extracellular Matrix Recycling as a Novel Plasticity Mechanism With a Potential Role in Disease

Authors Dankovich TM, Rizzoli SO Journal Frontiers in Cellular Neuroscience Citation Front Cell Neurosci. 2022 Mar 31;16:854897. Abstract The extracellular matrix (ECM) stabilizes neural circuits and synapses in the healthy brain, while also retaining the ability to be remodeled, to allow synapses to be plastic. A well-described mechanism for ECM
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29.03.2022

Roles and dynamics of 3-methylcytidine in cellular RNAs

Authors Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Mar 29:S0968-0004(22)00063-9. Abstract Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m3C) has recently come to the fore through the identification of the
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