2021

Authors Ghosh A, Chizhik AI, Karedla N, Enderlein J Journal Nature Protocols Citation Nat Protoc (2021). Abstract Super-resolution fluorescence imaging that surpasses the classical optical resolution limit is widely utilized for resolving the spatial organization of biological structures at molecular length scales. In one example, single-molecule localization microscopy, the lateral

Authors Martinez Hernandez A, Silbern I, Geffers I, Tatenhorst L, Becker S, Urlaub H, Zweckstetter M, Griesinger C, Eichele G Journal Frontiers in Neuroscience Citation Front Neurosci. 2021 Jun 17;15:643391. Abstract α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease

Authors Rosado-Ramos R, Godinho-Pereira J, Marques D, Figueira I, Fleming Outeiro T, Menezes R, Nunes Dos Santos C Journal Molecules Citation Molecules. 2021 Jun 2;26(11):3353. Abstract Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor

Authors Kloos M, Sharma A, Enderlein J, Diederichsen U Journal Journal of Peptide Science Citation J Pept Sci. 2021 Jun 2:e3355. Abstract β-Peptides are known to form 14-helices with high conformational rigidity, helical persistence length, and well-defined spacing and orientation regularity of amino acid side chains. Therefore, β-peptides are well

Authors Willig KI, Wegner W, Müller A, Calvet-Fournier V, Steffens H Journal Cell Reports Citation Cell Reports. 2021 Jun 1; 35 (9) 109192. Abstract Despite the tremendous success of super-resolution microscopy, multi-color in vivo applications are still rare. Here we present live-cell multi-label STED microscopy in vivo and in vitro

Authors del Álamo M, Li H, Munk A Journal The Annals of Statistics Citation Ann. Statist. 49(3): 1318-1346 (June 2021). Abstract Despite the popularity and practical success of total variation (TV) regularization for function estimation, surprisingly little is known about its theoretical performance in a statistical setting. While TV regularization

Authors Klemp HG, Kettwig M, Streit F, Gärtner J, Rosewich H, Krätzner R Journal Metabolites Citation Metabolites. 2021 May 29;11(6):347. Abstract Peroxisomes are central hubs for cell metabolism and their dysfunction is linked to devastating human disorders, such as peroxisomal biogenesis disorders and single peroxisomal enzyme/protein deficiencies. For decades, biochemical

Authors Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P Journal Nature Communications Citation Nat Commun. 2021 May 28;12(1):3232. Abstract Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like

Authors Teiwes NK, Mey I, Baumann PC, Strieker L, Unkelbach U, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25805-25812. Abstract Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a

Authors Fianu I, Dienemann C, Aibara S, Schilbach S, Cramer P Journal Communications Biology Citation Commun Biol. 2021 May 21;4(1):606. Abstract Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with human