2021

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane

Authors Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M Journal Molecular Therapy Citation Mol Ther. 2021 Apr 30;S1525-0016(21)00249-5.

Authors Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, Urlaub H, Cramer P Journal Journal of Biological Chemistry Citation J Biol Chem. 2021 Apr 29:100734. Abstract The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex Mediator, which regulates gene transcription by RNA

Authors Weish P, Lázaro DF, Palmares L, Santos PI, Stadelmann C, Höglinger GU, Rizzoli SO, Outeiro TF Journal bioRxiv Citation bioRxiv 2021.04.25.441304. Abstract Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson’s disease and other progressive neurodegenerative disorders known as Lewy body diseases (LBD). These proteinaceous deposits are immunopositive

Authors Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R Journal Structure Citation Structure 2021 Apr 26:S0969-2126(21)00119-2 (in press). Abstract The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington’s

Authors Pelizzola M, Behr M, Li H, Munk A, Futschik A Journal Nature Computational Science Citation Nat Comput Sci 1, 262–271 (2021). Abstract Because haplotype information is of widespread interest in biomedical applications, effort has been put into their reconstruction. Here, we propose an efficient method, called haploSep, that is

Authors Sundaram SM, Garg P, Leßlich HM, Mathivanan S Journal Journal of Physiology Citation J Physiol. 2021 Jun;599(11):2793-2795. Abstract No abstract available. DOI 10.1113/JP2812364   Pubmed Link  

Authors Baeuerlein FJB, Pastor-Pareja JC, Fernandez-Busnadiego R Journal bioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to tissues, as they usually require high-pressure freezing for vitrification. Here we

Authors Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R Journal Nature Communications Citation Nat Commun 12, 2110 (2021). Abstract The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were

Authors Kettwig M, Klemp H, Nessler S, Streit F, Krätzner R, Rosewich H, Gärtner J Journal Journal of Inherited Metabolic Disease Citation J Inherit Metab Dis 2021 Apr 14. Abstract X-linked adrenoleukodystrophy (X-ALD) is the most common leukodystrophy. Despite intensive research in recent years, it remains unclear, what drives the