2019

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25.12.2019

Loop formation and translational diffusion of intrinsically disordered proteins

Authors Muhle S, Zhou M, Ghosh A, Enderlein J Journal Physical Review E Citation Phys Rev E. 2019 Nov;100(5-1):052405. Abstract The conformational flexibility and dynamics of unfolded peptide chains is of major interest in the context of protein folding and protein functioning. The rate with which amino acids at different
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20.12.2019

(11) C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson’s Disease That Binds to alpha-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier

Authors Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, Schmidt F, Weckbecker D, Linder R, Bender D, Giese A, Pichler BJ, Griesinger C Journal ChemMedChem Citation ChemMedChem. 2020 Mar 5;15(5):411-415. Abstract There is an urgent clinical need for imaging of alpha-synuclein (alphaSyn) fibrils, the hallmark biomarker
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19.12.2019

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

Authors Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K Journal European Journal of Heart Failure Citation Eur J Heart
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13.12.2019

The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.
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12.12.2019

Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes

Authors Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P Journal Cell Citation Cell. 2019 Dec 12;179(7):1525-1536.e12. Abstract Poxviruses use virus-encoded multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m(7)G-capped mRNAs in the host cytoplasm. In the accompanying paper, we report structures
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12.12.2019

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes

Authors Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U Journal Cell Citation Cell. 2019 Dec 12;179(7):1537-1550.e19. Abstract Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out
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10.12.2019

The recurrent postzygotic pathogenic variant p.Glu47Lys in RHOA causes a novel recognizable neuroectodermal phenotype

Authors Yigit G, Saida K, DeMarzo D, Miyake N, Fujita A, Yang Tan T, White SM, Wadley A, Toliat MR, Motameny S, Franitza M, Stutterd CA, Chong PF, Kira R, Sengoku T, Ogata K, Guillen Sacoto MJ, Fresen C, Beck, BB, Nurnberg P. Dieterich C, Wollnik B, Matsumoto N, Altmuller
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08.12.2019

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs
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08.12.2019

Graphene-based metal-induced energy transfer for sub-nanometre optical localization

Authors Ghosh A, Sharma A, Chizhik AI, Isbaner S, Ruhlandt D, Tsukanov R, Gregor I, Karedla N, Enderlein J Journal Nature Photonics Citation Nat. Photonics 13, 860–865 (2019). Abstract Single-molecule fluorescence imaging has become an indispensable tool for almost all fields of research, from fundamental physics to the life sciences.
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05.12.2019

A mass spectrometry workflow for measuring protein turnover rates in vivo

Authors Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF Journal Nature Protocols Citation Nat Protoc. 2019 Dec;14(12):3333-3365. Abstract Proteins are continually produced and degraded, to avoid the accumulation of old or damaged molecules and to maintain the efficiency of physiological processes. Despite its importance, protein turnover
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