Latest Publications

Authors Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY Journal Science Reports Citation Sci Rep 12, 2987 (2022). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different

Authors Al-Azzani M, König A, Outeiro TF Journal Biomolecules Citation Biomolecules 2022, 12(2), 324. Abstract Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be associated

Authors Martinez-Sanchez A, Baumeister W, Lučić V Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Feb 15;218:106693.  Abstract Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution.

Authors Chowdhury A, Witte S, Aich A Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Feb 11;10:796066.  Abstract Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from generating energy, regulating the metabolic processes, cell death to inflammation. The most prominent

Authors Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D Journal Nature Communications Citation Nat Commun. 2022 Feb 11;13(1):838. Abstract

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with

Authors Feuda R, Menon AK, Göpfert MC Journal Molecular Biology and Evolution Citation Mol Biol Evol. 2022 Feb 10:msac033. Abstract Opsins, the protein moieties of animal visual photo-pigments, have emerged as moonlighting proteins with diverse, light-dependent and -independent physiological functions. This raises the need to revise some basic assumptions concerning

Authors Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G, Wollnik B Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 Jan 31:ddab373. Abstract Bloom syndrome (BS) is an autosomal recessive disease clinically characterized by primary microcephaly, growth deficiency, immunodeficiency, and

Authors Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C Journal Nature Communications Citation Nat Commun. 2022 Jan 27;13(1):545. Abstract Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy

Authors Simeth NA Journal Angewandte Chemie (International Edition) Citation Angew Chem Int Ed Engl. 2022 Jan 27:e202115145. Abstract Artificial molecular pumps that perform unidirectional motion on the molecular scale have been used to design systems operating away from equilibrium. Crafting such pumps onto a surface allows their unidirectional movement to