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08.03.2022

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Authors Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S Journal Neuron Citation Neuron. 2022 Mar 4:S0896-6273(22)00146-5. Abstract Vesicular transporters (VTs) define the
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08.03.2022

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

Authors Haupt LP, Rebs S, Maurer W, Hübscher D, Tiburcy M, Pabel S, Maus A, Köhne S, Tappu R, Haas J, Li Y, Sasse A, Santos CCX, Dressel R, Wojnowski L, Bunt G, Möbius W, Shah AM, Meder B, Wollnik B, Sossalla S, Hasenfuss G, Streckfuss-Bömeke K Journal Basic Research
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08.03.2022

The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic

Authors Dankovich TM, Rizzoli SO Journal Frontiers in Synaptic Neuroscience Citation Front Synaptic Neurosci. 2022 Mar 8;14:854956. Abstract In the adult brain, synapses are tightly enwrapped by lattices of the extracellular matrix that consist of extremely long-lived molecules. These lattices are deemed to stabilize synapses, restrict the reorganization of their
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07.03.2022

Non-Invasive Optical Motion Tracking Allows Monitoring of Respiratory Dynamics in Dystrophin-Deficient Mice

Authors Svetlove A, Albers J, Hülsmann S, Markus MA, Zschüntzsch J, Alves F, Dullin C Journal Cells Citation Cells. 2022 Mar 7;11(5):918. Abstract Duchenne muscular dystrophy (DMD) is the most common x-chromosomal inherited dystrophinopathy which leads to progressive muscle weakness and a premature death due to cardiorespiratory dysfunction. The mdx
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04.03.2022

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Authors Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W Journal Nature Communications Citation Nat Commun. 2022 Mar 4;13(1):1163.  Abstract Myelin, the electrically insulating sheath on axons, undergoes dynamic
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02.03.2022

Imaging of arrhythmia: Real-time cardiac magnetic resonance imaging in atrial fibrillation

Authors Laubrock K, von Loesch T, Steinmetz M, Lotz J, Frahm J, Uecker M, Unterberg-Buchwald C Journal European Journal of Radiology Open Citation Eur J Radiol Open. 2022 Mar 2;9:100404. Abstract Objectives: Quantitative evaluations of function, volume and mass are fundamental in the diagnostic workup of different cardiovascular diseases and
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28.02.2022

Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact
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26.02.2022

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome

Authors Gönenc II, Elcioglu NH, Martinez Grijalva C, Aras S, Großmann N, Praulich I, Altmüller J, Kaulfuß S, Li Y, Nürnberg P, Burfeind P, Yigit G, Wollnik B Journal Clinical Genetics Citation Clin Genet. 2022 Feb 26. Abstract Bloom syndrome (BS) is an autosomal recessive disorder with characteristic clinical features of
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24.02.2022

A new form of axonal pathology in a spinal model of neuromyelitis optica

Authors Herwerth M, Kenet S, Schifferer M, Winkler A, Weber M, Snaidero N, Wang M, Lohrberg M, Bennett JL, Stadelmann C, Hemmer B, Misgeld T Journal Brain Citation Brain, 2022;, awac079. Abstract Neuromyelitis optica (NMO) is a chronic neuroinflammatory disease, which primarily targets astrocytes and often results in severe axon
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23.02.2022

Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy

Authors Wegner W, Steffens H, Gregor C, Wolf F, Willig KI Journal Elife Citation eLife 2022;11:e73603. Abstract Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the environmental enrichment alters
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