Latest Publications

Authors Shaib AH, Chouaib AA, Imani V, Chowdhury R, Georgiev SV, Mougios N, Monga M, Reshetniak S, Mihaylov D, Chen H, Fatehbasharzad P, Crzan D, Saal KA, Trenkwalder C, Mollenhauer B, Outeiro TF, Preobraschenski J, Becherer U, Moser T, Boyden ES, Aricescu AR, Sauer M, Opazo F, Rizzoli SO Journal

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V Journal Biology Citation Biology (Basel). 2022 Aug 3;11(8):1164. Abstract Lead is a heavy metal whose widespread use has resulted in environmental contamination and significant health problems, particularly if the exposure occurs during developmental stages. It is a cumulative toxicant

Authors Dullin C, Svetlove A, Zschüntzsch J, Alves F Journal Scientific Reports Citation Sci Rep. 2022 Aug 2;12(1):13299. Abstract Retrospective gating (RG) is a well established technique in preclinical computed tomography (CT) to assess 3D morphology of the lung. In RG additional angular projections are recorded typically by performing multiple

Authors Chakraborty S, Martinez-Sanchez A, Beck F, Toro-Nahuelpan M, Hwang IY, Noh KM, Baumeister W, Mahamid J Journal BioRxiv Citation bioRxiv 2022.07.28.501854. Abstract Functional architecture of the neuronal microtubule (MT) cytoskeleton is maintained by various MT-associated proteins (MAPs), most of which bind to the MT outer surface. Yet, electron microscopy

Authors Lange T, Backhaus SJ, Beuthner BE, Topci R, Rigorth KR, Kowallick JT, Evertz R, Schnelle M, Ravassa S, Díez J, Toischer K, Seidler T, Puls M, Hasenfuß G, Schuster A Journal Journal of Cardiovascular Magnetic Resonance Citation J Cardiovasc Magn Reson. 2022 Jul 28;24(1):45. Abstract Background: Since cardiovascular magnetic

Authors Kaiyrzhanov R, Perry L, Rocca C, Zaki MS, Hosny H, Araujo Martins Moreno C, Phadke R, Zaharieva I, Camelo Gontijo C, Beetz C, Pini V, Movahedinia M, Zanoteli E, DiTroia S, Vuillaumier-Barrot S, Isapof A, Mehrjardi MYV, Ghasemi N, Sarkozy A, Muntoni F, Whalen S, Vona B, Houlden H,

Authors Santos GL, DeGrave AN, Rehman A, Al Disi S, Xhaxho K, Schröder H, Bao G, Meyer T, Tiburcy M, Dworatzek E, Zimmermann WH, Lutz S Journal Biomaterials Advances Citation Biomater Adv. 2022 Jul 21:213041. Abstract Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs

Authors Seefelder M, Klein FAC, Landwehrmeyer B, Fernández-Busnadiego R, Kochanek S Journal Journal of Huntington’s Disease Citation J Huntingtons Dis. 2022 Jul 16. Abstract Since the discovery of the mutation causing Huntington’s disease (HD) in 1993, it has been debated whether an expanded polyglutamine (polyQ) stretch affects the properties of

Authors Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2022 Jul 14:e15798. Abstract Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for

Authors Farnung L, Ochmann M, Garg G, Vos SM, Cramer P Journal Molecular Cell Citation Mol Cell. 2022 Jul 13:S1097-2765(22)00610-4. Abstract During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the help of various elongation factors. Here, we show that RNA Pol II achieves efficient nucleosome passage