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29.02.2024

Variance sum rule for entropy production

Authors Di Terlizzi I, Gironella M, Herraez-Aguilar D, Betz T, Monroy F, Baiesi M, Ritort F   Journal Science   Citation Science. 2024 Mar;383(6686):971-976.   Abstract Entropy production is the hallmark of nonequilibrium physics, quantifying irreversibility, dissipation, and the efficiency of energy transduction processes. Despite many efforts, its measurement at
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21.10.2022

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

Authors Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M Journal Science Citation Oct 21;378(6617):eabq4835. Abstract Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for
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27.05.2022

Remote control of the heart and beyond

Authors Zimmermann WH Journal Science Citation Science. 2022 May 27;376(6596):917-918. Abstract A resorbable closed-loop sensor-actuator implant can temporarily control heart rate. DOI 10.1126/science.abq0605 Pubmed Link  
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11.02.2022

Mechanism of spindle pole organization and instability in human oocytes

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with
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11.11.2021

Structural basis of Integrator-mediated transcription regulation

Authors Fianu I, Chen Y, Dienemann Ch, Dybkov O, Linden A, Urlaub H, Cramer P Journal Science Citation Science. 2021 Nov 12;374(6569):883-887 Abstract Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the
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15.01.2021

Structure of a transcribing RNA polymerase II–U1 snRNP complex

Authors Zhang S, Aibara S, Vos SM, Agafonov DE, Lührmann R, Cramer P Journal Science Citation Science. 2021 Jan 15;371(6526):305-309. Abstract To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron
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20.10.2020

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Authors Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu
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