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29.07.2020

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as
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22.07.2020

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

Authors Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T Journal Science Translational Medicine Citation Sci. Transl. Med. 12, eabb8086 (2020). Abstract Cochlear implants provide the brain
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21.07.2020

Three-dimensional beating dynamics of Chlamy- domonas flagella

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal bioRxiv Citation bioRxiv 2020.07.20.212159. Abstract Axonemes are the basic structure of motile cilia and flagella, and the investigation of how they function and move requires rapid three-dimensional imaging. We built a multi-plane
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20.07.2020

Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels

Authors Bonnin EA, Rizzoli SO Journal Frontiers in Behavioral Neuroscience Citation Front Behav Neurosci. 2020 Jul 20;14:124. Abstract The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically
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06.07.2020

A comparative analysis of the mobility of 45 proteins in the synaptic bouton

Authors Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli S Journal EMBO Journal Citation EMBO J. 2020 Jul 6;e104596. Abstract Many proteins involved in synaptic transmission are well known, and their features, as their abundance or spatial distribution, have been analyzed
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06.07.2020

Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy

Authors Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2020;10.1161/CIRCULATIONAHA.119.044794.
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01.07.2020

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

Authors Jäckle K, Zeis T, Schaeren-Wiemers N, Junker A, van der Meer F, Kramann N, Stadelmann C, Brück W Journal Brain Citation Brain. 2020 Jul 1;143(7):2073-2088. Abstract Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that leads to demyelinated lesions in the grey and white matter. Inflammatory,
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01.07.2020

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27

Authors Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020;gkaa549. published online ahead of print, 2020 Jul 1. Abstract MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA
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29.06.2020

μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve

Authors Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2020 Jun 29;e12387. Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half
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25.06.2020

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

Authors Jean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D, Kroll J, Nardis C, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T Journal Nature Communications Citation Nat Comm. 2020 Jun 25;11(1):3208. Abstract Inner hair cells (IHCs) are the primary receptors for hearing.
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