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23.01.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal BioRxiv Citation bioRxiv 2025.01.23.634455. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are close to the diffraction
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23.01.2025

Leonardo: A Toolset to Remove Sample-Induced Aberrations in Light Sheet Microscopy Images

Authors Liu Y, Müller G, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roeßing M, Stenzel M, Grüneboom A, Paetzold J, Ertürk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal Research Square Citation Research Square 2025. Abstract Selective plane illumination microscopy (SPIM, also known
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22.01.2025

A Photoswitchable Tryptophan Zipper – (Un)folding Fibrils in Seconds

Authors Cotroneo ER, Cheng TC, Kaltschnee L, Maibach P, Engelke M, Schwegler N, Thomas F, Thiele CM, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Peptides and proteins, that have the tendency to form aggregates, are often discussed in the context of Alz-heimer’s, Huntington’s, or Parkinson’s disease. However, studying aggregation
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22.01.2025

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation

Authors Maestro-Lopez M, Cheng TC, Muntaner J, Menendez M, Alonso M, Schweitzer A, Cuellar J, Valpuesta JM, Sakata E Journal BioRxiv Citation bioRxiv 2025.01.22.633148. Abstract The 26S proteasome primarily degrades proteins marked by polyubiquitin chains. Although ubiquitin-independent pathways for proteasomal degradation exist, the mechanisms involved remain poorly understood. Bag1 links
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22.01.2025

3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensors

Authors Jimenez AJ, Isensee J, Hofemeier A, Krueger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal BioRxiv Citation bioRxiv 2025.01.22.633835. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological phenomena such as cancer
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22.01.2025

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Authors Frohn J, Böddeker F, Reichardt M, Bruns H, Czajka T, Khan A, Broche L, Krisch M, Bravin A, Alves F, Zschüntzsch J, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Jan 22;15(1):2766. Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is
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20.01.2025

Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings

Authors Requardt R, Fink M, Kubica P, Steinem C, Munk A, Li H   Journal IEEE Transactions on NanoBioScience (TNB)   Citation IEEE Transactions on NanoBioScience (TNB). 2025.   Abstract Recent experimental studies have shed light on the intriguing possibility that ion channels exhibit cooperative behaviour. However, a comprehensive understanding
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20.01.2025

MedicoSAM: Towards foundation models for medical image segmentation

Authors Archit A, Freckmann L, Pape C Journal Arxiv Citation arXiv:2501.11734. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models or adapting
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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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16.01.2025

Super-resolution going viral: T4 virus particles as versatile 3D-Bio-NanoRulers

Authors Gallea JI, Nevskyi O, Kaźmierczak Z, Gligonov I, Chen T, Miernikiewicz P, Chizhik AM, Reinkensmeier L, Dąbrowska K, Bates M, Enderlein J Journal Advanced Materials Citation Adv Mater. 2025 Jan 16:e2403365. Abstract In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications
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