Journal

Authors Wendland K, Irsfeld M, Schreiber K, Ternka K, Stadelmann C, Nessler S, Gärtner J, Kettwig M Journal Cell Death & Disease Citation Cell Death Dis. 2025 Dec 27. Abstract RNaseT2-deficient cystic leukoencephalopathy (CLE) presents with severe psychomotor retardation, cystic brain lesions, white matter alterations, and cerebral atrophy. The Rnaset2−/−

Authors Flores-León M, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2025 Dec 26. Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies

Authors Landt C, Held F, Kolotourou K, Guranda M, Vakrakou AG, Franz J, Thomas C, Schmiedeknecht MUH, Bergann K, Wrzos C, Endmayr V, Tsaktanis T, Zechel S, Ancău M, Misgeld T, Hakroush S, Hametner S, Rothhammer V, Höftberger R, Hemmer B, Stadelmann C, Nessler S Journal Neurology: Neuroimmunology and Neuroinflammation

Authors Dvoretskii S, Archit A, Pape C, Moore J, Nolden M Journal Arxiv Citation arXiv:2512.15820. Abstract Modern bioimage analysis approaches are data hungry, making it necessary for researchers to scavenge data beyond those collected within their (bio)imaging facilities. In addition to scale, bioimaging datasets must be accompanied with suitable, high-quality

Authors Basak S, Inamdar K, Pollack YG, Albert L, Jans DC, Jakobs S, Enderlein J, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2025.12.17.694880 Abstract Direct STORM relies on robust fluorophore blinking; observations suggest that AlexaFluor647 underperforms when coupled to nanobodies, thereby undermining the advantages of nanobodies. We show that

Authors Archit A, Freckmann L, Pape C Journal IEEE Transactions on Medical Imaging Citation IEEE Trans Med Imaging. 2025 Dec 17;PP. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models

Authors Maestro-Lopez M, Cheng TC, Muntaner J, Menendez M, Alonso M, Schweitzer A, Ishizaka M, Tomko Jr. RJ, Cuellar J, Valpuesta JM, Sakata E Journal Science Advances Citation Sci Adv. (2025). accepted manuscript. Abstract The 26S proteasome primarily degrades proteins marked by polyubiquitin chains. Although ubiquitin-independent pathways for proteasomal degradation

Authors Svennberg E, Merino JL, Andrade J, Anselmino M, Arbelo E, Boersma E, Boriani G, Breithardt G, Chung M, Chyou J, Cohen A, Nielsen JC, Dichtl W, Diederichsen SZ, Dobrev D, Doehner W, Dworatzek E, Fabritz L, Filgueiras-Rama D, Gimpelewitz C, Hack G, Hatem S, Healey J, Heidbuchel H, Hijazi

Authors Müller L, Sartori F, Dehning J, Eggl MF, Priesemann V Journal Arxiv Citation arXiv:2512.11454. Abstract Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but they impose considerable societal, individual, and economic costs. We developed a general optimization framework to balance costs related

Authors Suchan L, Li H, Munk A Journal Electronic Journal of Statistics Citation Electron. J. Statist. 19(2): 5925-5978 (2025). Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a