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04.10.2024

Structural basis of Nipah virus replication

Authors Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Journal BioRxiv Citation bioRxiv 2024.10.04.616610. Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its RNA-dependent RNA polymerase (RdRp)
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03.10.2024

Membrane tension regulation is required for wound repair

Authors Raj N, Weiss M, Vos BE, Weischer S, Brinkmann F, Betz T, Trappmann B, Gerke V Journal Advanced Science Citation Adv Sci (Weinh). 2024 Oct 3:e2402317. Abstract Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental and thus need to be repaired
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01.10.2024

Super-Resolution Axial Imaging for Quantifying Piconewton Traction Forces in Live-cells

Authors Wang DX, Kong DM, Enderlein J, Chen T Journal BioRxiv Citation bioRxiv 2024.10.01.615997. Abstract Cell mechanics play a pivotal role in regulating numerous biological processes. While super-resolution microscopy enables the imaging of cellular forces in the lateral dimension with sub-10-nanometer resolution, achieving comparable resolution along the axial dimension remains
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27.09.2024

Measuring 3-dimensional dynamics of membrane in living cell with metal-induced energy transfer imaging/spectroscopy

Authors Chen T, Gallea JI, Karedla N, Wang D, Enderlein J Journal BioRxiv Citation bioRxiv 2024.09.27.614973. Abstract The dynamics of cellular membranes are crucial for many essential cellular processes. Despite various methods available to study membrane dynamics, simultaneously measuring membrane diffusion and fluctuations within living cell membranes remains challenging. In
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25.09.2024

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

Authors Bergner CG, van der Meer F, Franz J, Vakrakou A, Würfel T, Nessler S, Schäfer L, Nau-Gietz C, Winkler A, Lagumersindez-Denis N, Wrzos C, Damkou IA, Sergiou C, Schultz V, Knauer C, Metz I, Bahn E, Rodriguez EG, Merkler D, Simons M, Stadelmann C Journal Brain Citation Brain. 2024
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25.09.2024

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Authors Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstteter M, Fernandez Busnadiego R, Zimprich A, Outeiro TF Journal MedRxiv Citation medRxiv 2024.09.23.24313864. Abstract Background: Parkinson’s
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24.09.2024

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts

Authors Ruiz-Orera J, Miller DC, Greiner J, Genehr C, Grammatikaki A, Blachut S, Mbebi J, Patone G, Myronova A, Adami E, Dewani N, Liang N, Hummel O, Muecke MB, Hildebrandt TB, Fritsch G, Schrade L, Zimmermann WH, Kondova I, Diecke S, van Heesch S, Hübner N Journal Nature Cardiovascular Research
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23.09.2024

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Authors Bharti A, Ajinkya K, Andrea MM, Ramos-Gomes F, Bohnenberger H, Ströbel P, Alves F, Klein O Journal npj Imaging Citation npj Imaging 2, 35 (2024). Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, accentuated by its heterogeneity and complex tumour microenvironment (TME). The role of
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23.09.2024

PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis

Authors Georgiev SV, Rizzoli SO Journal BioRxiv Citation bioRxiv 2024.09.23.614406. Abstract Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of the synaptic vesicle, have been especially popular. However,
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19.09.2024

Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT

Authors Engeholm M, Roske JJ, Oberbeckmann E, Dienemann C, Lidschreiber M, Cramer P, Farnung L Journal Molecular Cell Citation Mol Cell. 2024 Sep 19;84(18):3423-3437.e8. Abstract To maintain the nucleosome organization of transcribed genes, ATP-dependent chromatin remodelers collaborate with histone chaperones. Here, we show that at the 5′ ends of yeast
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