Nucleic Acids Research

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19.12.2023

GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners

Authors Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 19:gkad1202. Abstract Regulation of RNA helicase activity, often accomplished by protein cofactors, is
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05.12.2023

The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro

Authors Wicke D, Neumann P, Gößringer M, Chernev A, Davydov S, Poehlein A, Daniel R, Urlaub H, Hartmann RK, Ficner R, Stülke J Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 5:gkad1171. Abstract Even though Bacillus subtilis is one of the most studied organisms, no function has been
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07.06.2023

N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing

Authors Wang C, Ulryck N, Herzel L, Pythoud N, Kleiber N, Guérineau V, Jactel V, Moritz C, Bohnsack MT, Carapito C, Touboul D, Bohnsack KE, Graille M Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Jun 7:gkad487. Abstract Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent
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28.02.2022

Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

Authors Kolar MH, Nagy G, Kunkel J, Vaiana SM, Bock LV, Grubmüller H Journal Nucleic Acids Research Citation Nucleic Acids Res. 2022 Feb 28;50(4):2258-2269. Abstract The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact
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16.09.2021

Structure of an inactive RNA polymerase II dimer

Authors Aibara S, Dienemann Ch, Cramer P Journal Nucleic Acids Research Citation Nucleic Acids Research, 2021; Sep 16, gkab783 Abstract Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it
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02.12.2020

Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes

Authors Lavdovskaia E, Denks K, Nadler F, Steube E, Linden A, Urlaub H, Rodnina MV, Richter-Dennerlein R Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020 Dec 2;gkaa1132. Abstract Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure rapid and accurate synthesis of mitochondrial proteins. Defects in translation
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01.07.2020

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27

Authors Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020;gkaa549. published online ahead of print, 2020 Jul 1. Abstract MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA
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