Frontiers in Molecular Neuroscience

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22.08.2022

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
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22.06.2022

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

Authors Rosholm KR, Badone B, Karatsiompani S, Nagy D, Seibertz F, Voigt N, Bell DC Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 Jun 22;15:898717. Abstract In the Hollywood blockbuster “The Curious Case of Benjamin Button” a fantastical fable unfolds of a man’s life that travels through time
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03.05.2022

α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Authors Leite K, Garg P, Spitzner FP, Guerin Darvas S, Bähr M, Priesemann V, Kügler S Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 May 3;15:868790. Abstract α-synuclein (α-Syn) is intimately linked to synucleinopathies like Parkinson’s disease and dementia with Lewy bodies. However, the pathophysiological mechanisms that are
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20.08.2021

Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of
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16.06.2021

Loss of BAF complex in developing cortex perturbs radial neuronal migration in a WNT signaling-dependent manner

Authors Sokpor G, Kerimoglu C, Nguyen H, Pham L, Rosenbusch J, Wagener R, Nguyen HP, Fischer A, Staiger JF, Tuoc T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 16 June 2021, 14: 687581. Abstract Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization.
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12.04.2021

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Authors Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2021 Apr 12;14:659926. Abstract Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative
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23.03.2021

RIM-binding proteins are required for normal sound-encoding at afferent inner hair cell synapses

Authors Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:651935. Abstract The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, we
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11.03.2021

Developing fast, red-light optogenetic stimulation of spiral ganglion neurons for future optical cochlear implants

Authors Huet AT, Dombrowsik T, Rankovic V, Thirumalai A, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:635897. Abstract Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical
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07.01.2021

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf
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