Frontiers in Molecular Neuroscience

Home >> Publications >> Journal >> Frontiers in Molecular Neuroscience
Feature image not available
28.02.2024

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Authors Hain PJH, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 17:1351280. Abstract Introduction: Recently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic function independent of electrophysiological
Learn More
Feature image not available
12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
Learn More
Feature image not available
06.09.2023

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand
Learn More
Feature image not available
22.08.2022

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
Learn More
Feature image not available
22.06.2022

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

Authors Rosholm KR, Badone B, Karatsiompani S, Nagy D, Seibertz F, Voigt N, Bell DC Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 Jun 22;15:898717. Abstract In the Hollywood blockbuster “The Curious Case of Benjamin Button” a fantastical fable unfolds of a man’s life that travels through time
Learn More
Feature image not available
03.05.2022

α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Authors Leite K, Garg P, Spitzner FP, Guerin Darvas S, Bähr M, Priesemann V, Kügler S Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 May 3;15:868790. Abstract α-synuclein (α-Syn) is intimately linked to synucleinopathies like Parkinson’s disease and dementia with Lewy bodies. However, the pathophysiological mechanisms that are
Learn More
Feature image not available
20.08.2021

Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of
Learn More
Feature image not available
16.06.2021

Loss of BAF complex in developing cortex perturbs radial neuronal migration in a WNT signaling-dependent manner

Authors Sokpor G, Kerimoglu C, Nguyen H, Pham L, Rosenbusch J, Wagener R, Nguyen HP, Fischer A, Staiger JF, Tuoc T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 16 June 2021, 14: 687581. Abstract Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization.
Learn More
Feature image not available
12.04.2021

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Authors Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2021 Apr 12;14:659926. Abstract Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative
Learn More
Feature image not available
23.03.2021

RIM-binding proteins are required for normal sound-encoding at afferent inner hair cell synapses

Authors Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:651935. Abstract The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, we
Learn More
X
EN DE
X
X