ChemBioChem

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05.07.2024

Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies

Authors Gatzemeier LM, Meyer F, Outeiro TF Journal ChemBioChem Citation Chembiochem. 2024 Jul 5:e202400253. Abstract The chemical rules governing protein folding have intrigued generations of researchers for decades. With the advent of artificial intelligence (AI), prediction of protein structure has improved tremendously. However, there is still a level of analysis
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22.05.2023

Modulating Secondary Structure Motifs through Photo-labile Peptide Staples

Authors Lāce I, Bazzi S, Uranga J, Schirmacher A, Diederichsen U, Mata RA, Simeth NA Journal ChemBioChem Citation Chembiochem. 2023 May 22:e202300270. Abstract Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus
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