Biological Chemistry

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24.04.2024

Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy

Authors Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A Journal Biological Chemistry Citation Biol Chem. 2024 Apr 24. Abstract Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here,
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29.06.2023

Translation termination in human mitochondria – substrate specificity of mitochondrial release factors

Authors Nadler F, Richter-Dennerlein R Journal Biological Chemistry Citation Biol Chem. 2023 Jun 29. Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to
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20.04.2023

Influence of phosphorylation on intermediate filaments

Authors Kraxner J, Köster S Journal Biological Chemistry Citation Biol Chem. 2023 Apr 20. Abstract The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety
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