Wolf, Fred

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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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16.02.2024

Near-optimal information relay by the neuronal population of layer 4 barrel cortex

Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal BioRxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the coordinated activities of populations of neurons, which, in turn, depend on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. In Layer 4 of
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28.11.2023

Boosting of neural circuit chaos at the onset of collective oscillations

Authors Palmigiano A, Engelken R, Wolf F Journal eLife Citation eLife 12:RP90378. Abstract Neuronal spiking activity in cortical circuits is often temporally structured by collective rhythms. Rhythmic activity has been hypothesized to regulate temporal coding and to mediate the flexible routing of information flow across the cortex. Spiking neuronal circuits,
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13.09.2023

Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?

Authors Thümmler K, Wrzos C, Franz J, McElroy D, Cole JJ, Hayden L, Arseni D, Schwarz F, Junker A, Edgar JM, Kügler S, Neef A, Wolf F, Stadelmann C, Linington C. Journal Neuropathology and Applied Neurobiology Citation Neuropathol Appl Neurobiol. 2023 Sep 13:e12935. Abstract Aims: Fibroblast growth factor (FGF) signalling
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01.07.2023

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

Authors Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F   Journal Molecular Biology of the Cell   Citation Mol Biol Cell. 2023 Jul 1;34(8):ar81.   Abstract During embryonic development, dramatic cell shape changes and movements reshape the embryonic body plan.
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19.04.2023

Signatures of heterogeneity in the statistical structure of target state aligned ensembles

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.09719. Abstract Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that
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09.04.2023

Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F   Journal ArXiv   Citation arXiv:2304.04279.   Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse
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06.04.2023

Reverse-time analysis uncovers universality classes in directional biological dynamics

Authors Lenner N, Eule S, Großhans J, Wolf F Journal Arxiv Citation arXiv:2304.03226. Abstract Mesoscopic bio-systems typically evolve towards functionally important target states, such as cell-cycle checkpoints or decision boundaries for the release of specific behaviors. For the data-driven inference of the underlying directional out-of-equilibrium dynamics, we here develop a
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23.02.2022

Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy

Authors Wegner W, Steffens H, Gregor C, Wolf F, Willig KI Journal Elife Citation eLife 2022;11:e73603. Abstract Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the environmental enrichment alters
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09.06.2021

Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity

Authors Steffens H, Mott AC, Li S, Wegner W, Švehla P, Kan VWY, Wolf F, Liebscher S, Willig KI Journal Science Advances Citation Sci. Adv. 2021; 7 : eabf2806. Abstract Excitatory synapses on dendritic spines of pyramidal neurons are considered a central memory locus. To foster both continuous adaption and
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