Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal BioRxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the coordinated activities of populations of neurons, which, in turn, depend on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. In Layer 4 of
Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?
Authors Thümmler K, Wrzos C, Franz J, McElroy D, Cole JJ, Hayden L, Arseni D, Schwarz F, Junker A, Edgar JM, Kügler S, Neef A, Wolf F, Stadelmann C, Linington C. Journal Neuropathology and Applied Neurobiology Citation Neuropathol Appl Neurobiol. 2023 Sep 13:e12935. Abstract Aims: Fibroblast growth factor (FGF) signalling
Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins
Authors Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F Journal Molecular Biology of the Cell Citation Mol Biol Cell. 2023 Jul 1;34(8):ar81. Abstract During embryonic development, dramatic cell shape changes and movements reshape the embryonic body plan.
Authors Palmigiano A, Engelken R, Wolf F Journal BioRxiv Citation bioRxiv 2022.08.28.505598. Abstract Cortical networks in vivo exhibit highly irregular spiking activity to repeated stimuli. One source of such variability is network chaos, ever-present in spiking network models. In order to reliably and robustly represent and transmit information, cortical networks
Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.09719. Abstract Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that
Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise
Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.04279. Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse
Authors Lenner N, Eule S, Großhans J, Wolf F Journal Arxiv Citation arXiv:2304.03226. Abstract Mesoscopic bio-systems typically evolve towards functionally important target states, such as cell-cycle checkpoints or decision boundaries for the release of specific behaviors. For the data-driven inference of the underlying directional out-of-equilibrium dynamics, we here develop a
Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
Authors Wegner W, Steffens H, Gregor C, Wolf F, Willig KI Journal Elife Citation eLife 2022;11:e73603. Abstract Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the environmental enrichment alters
Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity
Authors Steffens H, Mott AC, Li S, Wegner W, Švehla P, Kan VWY, Wolf F, Liebscher S, Willig KI Journal Science Advances Citation Sci. Adv. 2021; 7 : eabf2806. Abstract Excitatory synapses on dendritic spines of pyramidal neurons are considered a central memory locus. To foster both continuous adaption and