Authors Lāce I, Bazzi S, Uranga J, Schirmacher A, Diederichsen U, Mata RA, Simeth NA Journal ChemBioChem Citation Chembiochem. 2023 May 22:e202300270. Abstract Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus
Authors Fu Y, Simeth NA, Toyoda R, Brilmayer R, Szymanski W, Feringa BL Journal Angewandte Chemie International Edition Citation Angew Chem Int Ed Engl. 2023 Feb 17:e202218203. Abstract Light-induced 9,10-phenanthrenequinone-electron-rich alkene (PQ-ERA) photocycloadditions are an attractive new type of photoclick reaction, featuring fast conversions and high biocompatibility.
Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion
Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in
Authors Corbet BP, Schlüter JM, Cotroneo ER, Crespi S, Simeth NA Journal European Journal of Organic Chemistry Citation Eur. J. Org. Chem. 2022, e202201140 Abstract Light-responsive molecules have seen a major advance in modulating biological functions in recent years. Especially photoswitches are highly attractive building blocks due to the reversible
Authors Simeth NA Journal Angewandte Chemie (International Edition) Citation Angew Chem Int Ed Engl. 2022 Jan 27:e202115145. Abstract Artificial molecular pumps that perform unidirectional motion on the molecular scale have been used to design systems operating away from equilibrium. Crafting such pumps onto a surface allows their unidirectional movement to