Schuh, Melina

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early

Authors Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J Journal Prenatal Diagnosis Citation Prenatal Diagnosis. 2021;1–11. Abstract The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei

Authors Thomas C, Cavazza T, Schuh M Journal Biochemical Society Transactions Citation Biochem Soc Trans. 2021 Jan 15:BST20200043. Abstract Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work