Schuh, Melina

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30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,
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02.02.2023

Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes

Authors Harasimov K, Uraji J, Mönnich EU, Holubcová Z, Elder K, Blayney M, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2023 Feb 2. Abstract Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly
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21.10.2022

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

Authors Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M Journal Science Citation Oct 21;378(6617):eabq4835. Abstract Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for
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06.09.2022

Aneuploidy in mammalian oocytes and the impact of maternal ageing

Authors Charalambous C, Webster A, Schuh M Journal Nature Reviews Molecular Cell Biology Citation Nat Rev Mol Cell Biol. 2022 Sep 6. Abstract During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo. However, human eggs frequently contain an incorrect
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11.02.2022

Mechanism of spindle pole organization and instability in human oocytes

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with
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07.05.2021

Parental genome unification is highly erroneous in mammalian embryos

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early
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22.03.2021

Origins and mechanisms leading to aneuploidy in human eggs

Authors Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J Journal Prenatal Diagnosis Citation Prenatal Diagnosis. 2021;1–11. Abstract The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than
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05.02.2021

Two mechanisms drive pronuclear migration in mouse zygotes

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei
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15.01.2021

Aneuploidy in human eggs: contributions of the meiotic spindle

Authors Thomas C, Cavazza T, Schuh M Journal Biochemical Society Transactions Citation Biochem Soc Trans. 2021 Jan 15:BST20200043. Abstract Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from
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14.01.2021

Phase Separation during Germline Development

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work
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