Salditt, Tim

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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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22.01.2025

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Authors Frohn J, Böddeker F, Reichardt M, Bruns H, Czajka T, Khan A, Broche L, Krisch M, Bravin A, Alves F, Zschüntzsch J, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Jan 22;15(1):2766. Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is
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03.01.2025

3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography

Authors Reichmann J, Schnurpfeil A, Mittelstädt S, Jensen PM, Dahl VA Dahl AB, Weide C, von Campenhausen E, Dejea H, Tafforeau P, Werlein C, Jonigk D, Ackermann M, Engel K, Gallwas J, Dietz A, Hasanov MF, Salditt T Journal PNAS Nexus Citation PNAS Nexus, Volume 4, Issue 1, January 2025,
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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18.09.2024

Volumetric changes of the enteric nervous system under physiological and pathological conditions measured using x-ray phase-contrast tomography

Authors Peruzzi N, Eckermann M, Frohn J, Salditt T, Ohlsson B, Bech M Journal JGH Open Citation JGH Open. 2024 Sep 18;8(9):e70027. Abstract Background and Aim: Full-thickness biopsies of the intestinal wall may be used to study and assess damage to the neurons of the enteric nervous system (ENS), that
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12.06.2024

X-ray phase-contrast tomography of cells manipulated with an optical stretcher

Authors Burchert JP, Frohn J, Rölleke U, Bruns H, Yu B, Gleber SC, Stange R, Busse M, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2024 Jul 1. Abstract X-rays can penetrate deeply into biological cells and thus allow for examination of their
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29.05.2024

3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing

Authors Reichmann J, Sarrazin C, Schmale S, Blaurock C, Balkema-Buschmann A, Schmitzer B, Salditt T Journal Scientific Reports Citation Sci Rep 14, 12348 (2024). Abstract X-ray Phase Contrast Tomography (XPCT) based on wavefield propagation has been established as a high resolution three-dimensional (3D) imaging modality, suitable to reconstruct the intricate
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28.05.2024

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Authors Reichmann J, Franz J, Eckermann M, Schulz K, Mollenhauer B, Stadelmann C, Salditt T   Journal MedRxiv   Citation medRxiv 2024.03.26.24304193.   Abstract This study leverages X-ray Phase-Contrast Tomography (XPCT) for detailed analysis of neurodegenerative diseases like Alzheimer’s and Parkinson’s, focusing on the 3D visualization and quantification of neuropathological
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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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02.11.2023

Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

Authors Shi R, Reichardt M, Fiegle DJ, Küpfer LK, Czajka T, Sun Z, Salditt T, Dendorfer A, Seidel T, Bruegmann T Journal Cardiovascular Research Citation Cardiovasc Res. 2023 Nov 2:cvad141. Abstract Aims: Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches
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