Richter-Dennerlein, Ricarda

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we

Authors Yousefi R, Cruz-Zaragoza LD, Valpadashi A, Hansohn C, Dahal D, Richter-Dennerlein R, Rizzoli S, Urlaub H, Rehling P, Pacheu-Grau D Journal Cell Reports Citation Cell Rep, 44, 115143. Abstract Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for

Authors Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2024 Jul 11. Abstract Mitochondria contain dedicated ribosomes

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although

Authors Nadler F, Richter-Dennerlein R Journal Biological Chemistry Citation Biol Chem. 2023 Jun 29. Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to

Authors Dennerlein S, Rehling P, Richter-Dennerlein R Journal FEBS Letters Citation FEBS Lett. 2023 May 29. Abstract Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1 Fo ATP synthase and four

Authors Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2022 Oct 27;13(1):6406. Abstract Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial

Authors Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P Journal Elife Citation Elife. 2021 Dec 31;10:e68213. Abstract Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system

Authors Nadlera F, Lavdovskaiaa E, Richter-Dennerlein R Journal RNA Biology Citation RNA Biol. 2021 Dec 20;1-15. Abstract The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13