Author

Authors Ehrlich DA, Schneider AC, Priesemann V, Wibral M, Makkeh A Journal Transactions on Machine Learning Research Citation Transactions on Machine Learning Research (2023). Abstract In neural networks, task-relevant information is represented jointly by groups of neurons. However, the specific way in which this mutual information about the classification label

Authors Reichmann J, Verleden SE, Kühnel M, Kamp JC, Werlein C, Neubert L, Müller JH, Bui TQ, Ackermann M, Jonigk D, Salditt T Journal Physics in Medicine and Biology Citation Phys Med Biol. 2023 May 11. Abstract As the central organ of the respiratory system, the human lung is responsible

Authors Schmitzová J, Cretu C, Dienemann C, Urlaub H, Pena V Journal Nature Citation Nature. 2023 May 10. Abstract Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact

Authors Makki A, Rehling P Journal Biological Chemistry Citation Biol Chem. 2023 May 9. Abstract Most mitochondrial proteins are nuclear-encoded and imported by the protein import machinery based on specific targeting signals. The proteins that carry an amino-terminal targeting signal (presequence) are imported via the presequence import pathway that involves

Authors Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ Journal Movement Disorders Citation Mov Disord. 2023 May 8. Abstract Background: More than 200 years

Authors Schröder S, Yigit G, Li Y, Altmüller J, Büttel HM, Fiedler B, Kretzschmar C, Nürnberg P, Seeger J, Serpieri V, Valente EM, Wollnik B, Boltshauser E, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2023 May 2;18(1):101. Abstract Background: The term congenital ocular motor

Authors Pinkert-Leetsch D, Frohn J, Ströbel P, Alves F, Salditt T, Missbach-Guentner J Journal Cancer Imaging Citation Cancer Imaging. 2023 May 2;23(1):43. Abstract Background: The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which still has one of the lowest survival rates, requires novel imaging tools to improve early detection and

Authors Rodnina MV Journal Annual Reviews of Biophysics Citation Annu. Rev. Biophys. 2023. 52:161–82. Abstract Faithful translation of messenger RNA (mRNA) into protein is essential to maintain protein homeostasis in the cell. Spontaneous translation errors are very rare due to stringent selection of cognate aminoacyl transfer RNAs (tRNAs) and the

Authors Busley AV, Cyganek L Journal Stem Cell Research Citation Stem Cell Res. 2023 Jun;69:103108. Abstract Patients harboring causative gene variants in RAS GTPase MRAS develop Noonan syndrome and early-onset hypertrophic cardiomyopathy. Here, we describe the generation of a human iPSC line harboring the Noonan syndrome-associated MRAS p.G23V variant by

Authors Busley AV, Kleinsorge M, Cyganek L   Journal Stem Cell Research   Citation Stem Cell Res. 2023 Apr 24;69:103105.   Abstract Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. Here,