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03.06.2024

Catching up but still miles behind — a patient registry for otoferlin

Authors Vona B, Wollnik B, Strenzke N, Moser T Journal Experimental & Molecular Medicine Citation Exp Mol Med (2024). Abstract No abstract available. DOI 10.1038/s12276-024-01247-6   Pubmed Link
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01.06.2024

Analyzing cross-talk between superimposed signals: Vector norm dependent hidden Markov models and applications to ion channels

Authors Vanegas LJ, Eltzner B, Rudolf D, Dura M, Lehnart SE, Munk A Journal The Annals of Applied Statistics Citation Ann. Appl. Stat. 18(2): 1445-1470. Abstract We propose and investigate a hidden Markov model (HMM) for the analysis of dependent, aggregated, superimposed two-state signal recordings. A major motivation for this
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01.06.2024

Through the Haze: Unveiling the Link Between Smoking and Atrial Fibrillation

Authors Mason FE, Voigt N Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jun 1;326(6):H1489-H1490. Abstract No abstract available. DOI 10.1152/ajpheart.00286.2024   Pubmed Link
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01.06.2024

Characterizing intracellular mechanics via optical tweezers-based microrheology

Authors Vos BE, Muenker TM, Betz T Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2024 Jun 1;88:102374. Abstract Intracellular organization is a highly regulated homeostatic state maintained to ensure eukaryotic cells’ correct and efficient functioning. Thanks to decades of research, vast knowledge of the proteins involved
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30.05.2024

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

Authors Bode D, Pronto JRD, Schiattarella GG, Voigt N Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 May 30. Abstract Atrial fibrillation (AF) is a continually growing health-care burden that often presents together with metabolic disorders, including diabetes mellitus and obesity. Current treatments often fall short of preventing AF
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29.05.2024

Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

Authors Muenker TM, Vos BE, Betz T Journal eLife Citation eLife13:RP97416. Abstract Living cells are complex entities that perform many different complex tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide
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29.05.2024

3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing

Authors Reichmann J, Sarrazin C, Schmale S, Blaurock C, Balkema-Buschmann A, Schmitzer B, Salditt T Journal Scientific Reports Citation Sci Rep 14, 12348 (2024). Abstract X-ray Phase Contrast Tomography (XPCT) based on wavefield propagation has been established as a high resolution three-dimensional (3D) imaging modality, suitable to reconstruct the intricate
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27.05.2024

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Authors Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A Journal Cells Citation Cells. 2024 May 27;13(11):923. Abstract Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic
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27.05.2024

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the
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23.05.2024

CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent
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